Microtubule nucleation is regulated by the γ-tubulin ring complex (γTuRC) and related γ-
tubulin complexes, providing spatial and temporal control over the initiation of microtubule …

BACKGROUND: Taxanes are established in the treatment of metastatic breast cancer (MBC)
and early breast cancer (EBC) as potent chemotherapy agents. However, their therapeutic …

The highly conserved protein γ-tubulin is required for microtubule nucleation in vivo. When
viewed in the electron microscope, a highly purified γtubulin complex from Xenopus …

Mammalian polo-like kinase 1 (Plk1) is structurally related to the polo gene product of
Drosophila melanogaster, Cdc5p of Saccharomyces cerevisiae, and plo1+ of …

Cilia formation is a multi-step process that starts with the docking of a vesicle at the distal
part of the mother centriole. This step marks the conversion of the mother centriole into the …

The γ-tubulin ring complex (γ-TuRC) is an essential regulator of centrosomal and
acentrosomal microtubule formation, yet its structure is not known. Here, we present a cryo …

Antlsem from scleroderma patients that react widely with centrosomes in plants and animals
were used to isolate cDNA8 encoding a novel centrosomal proteln. The nucleotlde …

Stimulation by the extracellular Hedgehog (Hh) protein signal has been shown to alter ciliary
localization of the mammalian Hh receptor components Smoothened (Smo) and Patched …

The development of genomic instability is a hallmark of high-risk human papillomavirus
(HPV) associated cervical carcinogenesis. We have previously shown that the HPV-16 E7 …

Loss of genomic integrity is a defining feature of many human malignancies, including
human papillomavirus (HPV)-associated preinvasive and invasive genital squamous …