The cumulative science linking stress to negative health outcomes is vast. Stress can affect
health directly, through autonomic and neuroendocrine responses, but also indirectly …

Through advances in both basic and clinical scientific research, Pavlovian fear conditioning
and extinction have become an exemplary translational model for understanding and …

The well-replicated observation that many people maintain mental health despite exposure
to severe psychological or physical adversity has ignited interest in the mechanisms that …

Anxiety disorders are the most common mental disorders and are often chronic and
disabling. Although exposure-based treatments are effective, a substantial number of …

Evidence from imaging and anatomical studies suggests that the midcingulate cortex (MCC)
is a dynamic hub lying at the interface of affect and cognition. In particular, this neural system …

Considerable work has advanced understanding of the nature, causes, management, and
prevention of anxiety disorders in children and adolescents over the past 30 years. Prior to …

From a combined neurobiological and evolution-theoretical perspective, the stress response
is a subcortically subserved response to uncertainty that is not 'generated'but 'default': the …

Early work stressed the differing involvement of the central amygdala (CeA) and bed
nucleus of the stria terminalis (BNST) in the genesis of fear versus anxiety, respectively. In …

It is widely thought that phasic and sustained responses to threat reflect dissociable circuits
centered on the central nucleus of the amygdala (Ce) and the bed nucleus of the stria …

The authors describe how contemporary learning theory and research provide the basis for
models of the etiology and maintenance of anxiety and related disorders. They argue that …