[HTML][HTML] White matter damage and degeneration in traumatic brain injury
Traumatic brain injury (TBI) is a complex condition that can resolve over time but all too often
leads to persistent symptoms, and the risk of poor patient outcomes increases with aging …
leads to persistent symptoms, and the risk of poor patient outcomes increases with aging …
Systems biology dissection of PTSD and MDD across brain regions, cell types, and blood
The molecular pathology of stress-related disorders remains elusive. Our brain multiregion,
multiomic study of posttraumatic stress disorder (PTSD) and major depressive disorder …
multiomic study of posttraumatic stress disorder (PTSD) and major depressive disorder …
[HTML][HTML] The gut microbiota–oligodendrocyte axis: A promising pathway for modulating oligodendrocyte homeostasis and demyelination-associated disorders
W Tang, Q Wang, M Sun, Y Huang, M Zhou, X Zhang… - Life Sciences, 2024 - Elsevier
The bidirectional regulation between the gut microbiota and brain, known as gut–brain axis,
has received significant attention. The myelin sheath, produced by oligodendrocytes or …
has received significant attention. The myelin sheath, produced by oligodendrocytes or …
Single-cell genomics and regulatory networks for 388 human brains
Single-cell genomics is a powerful tool for studying heterogeneous tissues such as the
brain. Yet little is understood about how genetic variants influence cell-level gene …
brain. Yet little is understood about how genetic variants influence cell-level gene …
escheR: unified multi-dimensional visualizations with Gestalt principles
The creation of effective visualizations is a fundamental component of data analysis. In
biomedical research, new challenges are emerging to visualize multi-dimensional data in a …
biomedical research, new challenges are emerging to visualize multi-dimensional data in a …
Topic Modeling analysis of the Allen Human Brain Atlas
The human brain is a complex interconnected structure controlling all elementary and high-
level cognitive tasks. It is composed of many regions that exhibit specific distributions of cell …
level cognitive tasks. It is composed of many regions that exhibit specific distributions of cell …
iMIRACLE: an Iterative Multi-View Graph Neural Network to Model Intercellular Gene Regulation from Spatial Transcriptomic Data
Spatial transcriptomics has transformed genomic research by measuring spatially resolved
gene expressions, allowing us to investigate how cells adapt to their microenvironment via …
gene expressions, allowing us to investigate how cells adapt to their microenvironment via …
Integrating gene expression and imaging data across Visium capture areas with visiumStitched
Background Visium is a widely-used spatially-resolved transcriptomics assay available from
10x Genomics. Standard Visium capture areas (6.5 mm by 6.5 mm) limit the survey of larger …
10x Genomics. Standard Visium capture areas (6.5 mm by 6.5 mm) limit the survey of larger …
High-risk neuropsychiatric copy number variants are associated with convergent transcriptomic changes in human brain cells
G Dugan, N Akula, S Marenco, P Auluck, A Raznahan… - bioRxiv, 2024 - biorxiv.org
Large, recurrent copy number variants (CNVs) are among the strongest risk factors for
neuropsychiatric conditions, contributing to multiple phenotypes with overlapping psychiatric …
neuropsychiatric conditions, contributing to multiple phenotypes with overlapping psychiatric …
Integrative genomics approach identifies glial transcriptomic dysregulation and risk in the cortex of individuals with Alcohol Use Disorder
Alcohol use disorder (AUD) is a prevalent neuropsychiatric disorder that is a major global
health concern, affecting millions of people worldwide. Past molecular studies of AUD used …
health concern, affecting millions of people worldwide. Past molecular studies of AUD used …