Computational investigations of hERG channel blockers: New insights and current predictive models
BO Villoutreix, O Taboureau - Advanced drug delivery reviews, 2015 - Elsevier
Identification of potential human Ether-a-go-go Related-Gene (hERG) potassium channel
blockers is an essential part of the drug development and drug safety process in …
blockers is an essential part of the drug development and drug safety process in …
Natural products modulating the hERG channel: heartaches and hope
Covering: 1996–December 2016 The human Ether-à-go-go Related Gene (hERG) channel
is a voltage-gated potassium channel playing an essential role in the normal electrical …
is a voltage-gated potassium channel playing an essential role in the normal electrical …
Isoquinoline alkaloids as prolyl oligopeptidase inhibitors
L Cahlíková, L Hulová, M Hrabinová, J Chlebek… - Fitoterapia, 2015 - Elsevier
Prolyl oligopeptidase is a cytosolic serine peptidase that hydrolyses proline-containing
peptides at the carboxy terminus of proline residues. It has been associated with …
peptides at the carboxy terminus of proline residues. It has been associated with …
Screening of the Pan-African natural product library identifies ixoratannin A-2 and boldine as novel HIV-1 inhibitors
I Tietjen, F Ntie-Kang, P Mwimanzi, PA Onguéné… - PLoS …, 2015 - journals.plos.org
The continued burden of HIV in resource-limited regions such as parts of sub-Saharan
Africa, combined with adverse effects and potential risks of resistance to existing …
Africa, combined with adverse effects and potential risks of resistance to existing …
California poppy (Eschscholzia californica), the Papaveraceae golden girl model organism for evodevo and specialized metabolism
California poppy or golden poppy (Eschscholzia californica) is the iconic state flower of
California, with native ranges from Northern California to Southwestern Mexico. It grows well …
California, with native ranges from Northern California to Southwestern Mexico. It grows well …
HPLC-based activity profiling for pharmacologically and toxicologically relevant natural products–principles and recent examples
M Hamburger - Pharmaceutical biology, 2019 - Taylor & Francis
Context: Discovery of pharmacologically active natural products as starting points for drug
development remains important and, for reasons of consumer safety, the identification of …
development remains important and, for reasons of consumer safety, the identification of …
Effects of Chelidonium majus extracts and major alkaloids on hERG potassium channels and on dog cardiac action potential—a safety approach
Chelidonium majus or greater celandine is spread throughout the world, and it is a very
common and frequent component of modern phytotherapy. Although C. majus contains …
common and frequent component of modern phytotherapy. Although C. majus contains …
Human ether-à-go-go related gene (hERG) channel blocking aporphine alkaloids from lotus leaves and their quantitative analysis in dietary weight loss supplements
Blockage of the human ether-à-go-go related gene (hERG) channel can result in life-
threatening ventricular tachyarrhythmia. In an in vitro screening of herbal materials for hERG …
threatening ventricular tachyarrhythmia. In an in vitro screening of herbal materials for hERG …
Boldo, its secondary metabolites and their derivatives
BK Cassels, G Fuentes-Barros… - Current Traditional …, 2019 - benthamdirect.com
Boldo leaves (Boldo folium, from Peumus boldus Mol.) are very frequently used as a
medicinal herb in Chile and are exported to many countries to be used in teas or as extracts …
medicinal herb in Chile and are exported to many countries to be used in teas or as extracts …
[HTML][HTML] A speedy route to sterically encumbered, benzene-fused derivatives of privileged, naturally occurring hexahydropyrrolo [1, 2-b] isoquinoline
O Bakulina, A Ivanov, V Suslonov… - Beilstein Journal of …, 2017 - beilstein-journals.org
A series of 15 benzene-fused hexahydropyrrolo [1, 2-b] isoquinolonic acids with substantial
degree of steric encumbrance has been prepared via a novel variant of the Castagnoli …
degree of steric encumbrance has been prepared via a novel variant of the Castagnoli …