[HTML][HTML] Mechanistic Insights into Clinically Relevant Ribosome-Targeting Antibiotics

SJ Krawczyk, M Leśniczak-Staszak, E Gowin… - Biomolecules, 2024 - mdpi.com
Antibiotics targeting the bacterial ribosome are essential to combating bacterial infections.
These antibiotics bind to various sites on the ribosome, inhibiting different stages of protein …

Multifunctional gelatin nanoparticle stabilized-Pickering emulsion hydrogel based on dextran and amikacin with controlled drug release and enhanced antibacterial …

R Zhang, X Huang, Q Wu, S Chu, X Bai, Y Zhou… - International Journal of …, 2024 - Elsevier
Plant essential oils possess broad-spectral antimicrobial property, but the applications are
impeded by their insolubility in water, extreme volatility, and strong irritation. Nanoparticle …

Hibernating ribosomes as drug targets?

CL Ekemezie, SV Melnikov - Frontiers in Microbiology, 2024 - frontiersin.org
When ribosome-targeting antibiotics attack actively growing bacteria, they occupy ribosomal
active centers, causing the ribosomes to stall or make errors that either halt cellular growth …

Selectivity and morphological engineering of a unique gallium− organic framework for antibiotics exclusion in water

M Barati, H Raissi, A Ghahari - npj Clean Water, 2024 - nature.com
Antibiotic pollutants from pharmaceutical waste pose a severe threat to ecosystems. This
study explores the use of gallium-metal organic frameworks (Ga-MOFs) and imide …

Wide‐Spectrum Nano‐Antibiotics Based on TPA‐Py@ AuNCs⊂ BSA for Multimodal Synergistic Therapy of Drug‐Resistant Bacteria and Wound Infections

FR Xu, GL Zhang, K Zhang, P Chen, Q Wang… - …, 2024 - Wiley Online Library
To meet the high requirements of biomedical applications in antimicrobial agents, it is crucial
to explore efficient nano‐antimicrobial agents with no resistance and good biocompatibility …

Antibiotics against Pseudomonas aeruginosa on Human Skin Cell Lines: Determination of the Highest Non-Cytotoxic Concentrations with Antibiofilm Capacity for …

MI Quiñones-Vico, A Fernández-González… - Pharmaceutics, 2024 - mdpi.com
Pseudomonas aeruginosa is one of the most common microorganisms causing infections of
severe skin wounds. Antibiotic or antiseptic treatments are crucial to prevent and curb these …

Tuning of ribosome levels mediated by RNase I and hibernating ribosomes

A Minami, T Tanzawa, Z Yang, T Funatsu, T Kuzuyama… - bioRxiv, 2024 - biorxiv.org
ribosome abundance is a significant concern for cells. Ribonucleases mediate ribosome
degradation in response to stresses, while some ribosomes deactivate translational activity …

Adaptive Evolution of the Bacterial Translation Machinery

A De Tarafder - 2024 - diva-portal.org
The process of protein synthesis via translation is of paramount importance for the existence
of life on Earth. The bacterial translation machinery has embraced more than 3.5 billion …

Investigating the Molecular Mechanism of Ribosome Recycling

SM Seely - 2024 - utmb-ir.tdl.org
In all living cells, the ribosome translates the genetic information carried by messenger
RNAs (mRNAs) into proteins. The process of ribosome recycling, a key step during protein …