[HTML][HTML] Mechanistic Insights into Clinically Relevant Ribosome-Targeting Antibiotics
SJ Krawczyk, M Leśniczak-Staszak, E Gowin… - Biomolecules, 2024 - mdpi.com
Antibiotics targeting the bacterial ribosome are essential to combating bacterial infections.
These antibiotics bind to various sites on the ribosome, inhibiting different stages of protein …
These antibiotics bind to various sites on the ribosome, inhibiting different stages of protein …
Multifunctional gelatin nanoparticle stabilized-Pickering emulsion hydrogel based on dextran and amikacin with controlled drug release and enhanced antibacterial …
R Zhang, X Huang, Q Wu, S Chu, X Bai, Y Zhou… - International Journal of …, 2024 - Elsevier
Plant essential oils possess broad-spectral antimicrobial property, but the applications are
impeded by their insolubility in water, extreme volatility, and strong irritation. Nanoparticle …
impeded by their insolubility in water, extreme volatility, and strong irritation. Nanoparticle …
Hibernating ribosomes as drug targets?
CL Ekemezie, SV Melnikov - Frontiers in Microbiology, 2024 - frontiersin.org
When ribosome-targeting antibiotics attack actively growing bacteria, they occupy ribosomal
active centers, causing the ribosomes to stall or make errors that either halt cellular growth …
active centers, causing the ribosomes to stall or make errors that either halt cellular growth …
Selectivity and morphological engineering of a unique gallium− organic framework for antibiotics exclusion in water
Antibiotic pollutants from pharmaceutical waste pose a severe threat to ecosystems. This
study explores the use of gallium-metal organic frameworks (Ga-MOFs) and imide …
study explores the use of gallium-metal organic frameworks (Ga-MOFs) and imide …
Wide‐Spectrum Nano‐Antibiotics Based on TPA‐Py@ AuNCs⊂ BSA for Multimodal Synergistic Therapy of Drug‐Resistant Bacteria and Wound Infections
To meet the high requirements of biomedical applications in antimicrobial agents, it is crucial
to explore efficient nano‐antimicrobial agents with no resistance and good biocompatibility …
to explore efficient nano‐antimicrobial agents with no resistance and good biocompatibility …
Antibiotics against Pseudomonas aeruginosa on Human Skin Cell Lines: Determination of the Highest Non-Cytotoxic Concentrations with Antibiofilm Capacity for …
MI Quiñones-Vico, A Fernández-González… - Pharmaceutics, 2024 - mdpi.com
Pseudomonas aeruginosa is one of the most common microorganisms causing infections of
severe skin wounds. Antibiotic or antiseptic treatments are crucial to prevent and curb these …
severe skin wounds. Antibiotic or antiseptic treatments are crucial to prevent and curb these …
Tuning of ribosome levels mediated by RNase I and hibernating ribosomes
ribosome abundance is a significant concern for cells. Ribonucleases mediate ribosome
degradation in response to stresses, while some ribosomes deactivate translational activity …
degradation in response to stresses, while some ribosomes deactivate translational activity …
Adaptive Evolution of the Bacterial Translation Machinery
A De Tarafder - 2024 - diva-portal.org
The process of protein synthesis via translation is of paramount importance for the existence
of life on Earth. The bacterial translation machinery has embraced more than 3.5 billion …
of life on Earth. The bacterial translation machinery has embraced more than 3.5 billion …
Investigating the Molecular Mechanism of Ribosome Recycling
SM Seely - 2024 - utmb-ir.tdl.org
In all living cells, the ribosome translates the genetic information carried by messenger
RNAs (mRNAs) into proteins. The process of ribosome recycling, a key step during protein …
RNAs (mRNAs) into proteins. The process of ribosome recycling, a key step during protein …