Homology modeling is one of the computational structure prediction methods that are used
to determine protein 3D structure from its amino acid sequence. It is considered to be the …

Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder in the
world. Motor impairment seen in PD is associated with dopaminergic neurotoxicity in the …

Stimulation of cells with TNFα can promote distinct cell death pathways, including RIPK1-
independent apoptosis, necroptosis, and RIPK1-dependent apoptosis (RDA)—the latter of …

Long-term exposure to elevated levels of manganese (Mn) causes manganism, a
neurodegenerative disorder with Parkinson's disease (PD)-like symptoms. Increasing …

Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting millions of
people worldwide. Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) are …

Leucine-Rich Repeat Kinase 2 (LRRK2) is a large, multidomain protein with dual kinase and
GTPase function that is commonly mutated in both familial and idiopathic Parkinson's …

Animal toxins present a major threat to human health worldwide, predominantly through
snakebite envenomings, which are responsible for over 100,000 deaths each year. To date …

Parkinson's disease is one of the most common neurodegenerative diseases affecting the
ageing population, with a prevalence that has doubled over the last 30 years. As the …

Missense mutations along the leucine-rich repeat kinase 2 (LRRK2) protein are a major
contributor to Parkinson's Disease (PD), the second most commonly occurring …

Mutations in the multidomain protein Leucine-rich-repeat kinase 2 (LRRK2) have been
identified as a genetic risk factor for both sporadic and familial Parkinson's disease (PD) …