The coming decade in precision oncology: six riddles

A Wahida, L Buschhorn, S Fröhling, PJ Jost… - Nature Reviews …, 2023 - nature.com
High-throughput methods to investigate tumour omic landscapes have quickly catapulted
cancer specialists into the precision oncology era. The singular lesson of precision oncology …

Impact of risk factors on early cancer evolution

CE Weeden, W Hill, EL Lim, E Grönroos, C Swanton - Cell, 2023 - cell.com
Recent identification of oncogenic cells within healthy tissues and the prevalence of indolent
cancers found incidentally at autopsies reveal a greater complexity in tumor initiation than …

Lung adenocarcinoma promotion by air pollutants

W Hill, EL Lim, CE Weeden, C Lee, M Augustine… - Nature, 2023 - nature.com
A complete understanding of how exposure to environmental substances promotes cancer
formation is lacking. More than 70 years ago, tumorigenesis was proposed to occur in a two …

[HTML][HTML] Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA

EN Bergstrom, J Luebeck, M Petljak, A Khandekar… - Nature, 2022 - nature.com
Clustered somatic mutations are common in cancer genomes and previous analyses reveal
several types of clustered single-base substitutions, which include doublet-and multi-base …

[HTML][HTML] Uncovering novel mutational signatures by de novo extraction with SigProfilerExtractor

SMA Islam, M Díaz-Gay, Y Wu, M Barnes, R Vangara… - Cell genomics, 2022 - cell.com
Mutational signature analysis is commonly performed in cancer genomic studies. Here, we
present SigProfilerExtractor, an automated tool for de novo extraction of mutational …

[HTML][HTML] Current status and future prospects for esophageal cancer

M Sheikh, G Roshandel, V McCormack, R Malekzadeh - Cancers, 2023 - mdpi.com
Simple Summary Over 500,000 individuals died due to esophageal cancer (EC) worldwide
in 2020. More than four decades of etiological research have predominantly focused on the …

[HTML][HTML] The translational challenges of precision oncology

O Pich, C Bailey, TBK Watkins, S Zaccaria… - Cancer Cell, 2022 - cell.com
The translational challenges in the field of precision oncology are in part related to the
biological complexity and diversity of this disease. Technological advances in genomics …

Aristolochic acid-associated cancers: a public health risk in need of global action

S Das, S Thakur, M Korenjak, VS Sidorenko… - Nature Reviews …, 2022 - nature.com
Aristolochic acids (AAs) are a group of naturally occurring compounds present in many plant
species of the Aristolochiaceae family. Exposure to AA is a significant risk factor for severe …

[HTML][HTML] Genomic alterations driving precancerous to cancerous lesions in esophageal cancer development

J Chang, X Zhao, Y Wang, T Liu, C Zhong, Y Lao… - Cancer Cell, 2023 - cell.com
Esophageal squamous cell carcinoma (ESCC) develops through a series of increasingly
abnormal precancerous lesions. Previous studies have revealed the striking differences …

Identifying novel causes of cancers to enhance cancer prevention: new strategies are needed

P Brennan, G Davey-Smith - JNCI: Journal of the National …, 2022 - academic.oup.com
The burden of cancer from a clinical, societal, and economic viewpoint continues to increase
in all parts of the world, along with much debate regarding how to confront this. Projected …