An increasing number of epilepsies are being attributed to variants in genes with epigenetic
functions. The products of these genes include factors that regulate the structure and …

Rett Syndrome (RTT) is a rare and severe X-linked developmental brain disorder that occurs
primarily in females, with a ratio of 1: 10.000. De novo mutations in the Methyl-CpG Binding …

Abnormalities in GABAergic inhibitory circuits have been implicated in the aetiology of
autism spectrum disorder (ASD). ASD is caused by genetic and environmental factors …

Congenital alterations in the levels of the transcription factor Forkhead box g1 (FOXG1)
coding gene trigger" FOXG1 syndrome," a spectrum that recapitulates birth defects found in …

Abstract MECP2 duplication syndrome (MDS), a rare X‐linked genomic disorder affecting
predominantly males, is caused by duplication of the chromosomal region containing the …

Background FOXG1-related encephalopathy, also known as FOXG1 syndrome or FOXG1-
related disorder, affects most aspects of development and causes microcephaly and brain …

FOXG1 syndrome is a rare neurodevelopmental disorder associated with severe cognitive
dysfunction, autistic behavior, and early‐onset hyperkinetic movement disorders. Patients …

Cortical GABAergic interneurons are critical components of neural networks. They provide
local and long-range inhibition and help coordinate network activities involved in various …

Neurodevelopmental disorders (NDDs) are a heterogeneous and highly prevalent group of
psychiatric conditions marked by impairments in the nervous system. Their onset occurs …

The transcription factor FOXG1 serves pleiotropic functions in brain development ranging
from the regulation of precursor proliferation to the control of cortical circuit formation. Loss …