The expanding universe of PARP1-mediated molecular and therapeutic mechanisms
D Huang, WL Kraus - Molecular cell, 2022 - cell.com
ADP-ribosylation (ADPRylation) is a post-translational modification of proteins catalyzed by
ADP-ribosyl transferase (ART) enzymes, including nuclear PARPs (eg, PARP1 and PARP2) …
ADP-ribosyl transferase (ART) enzymes, including nuclear PARPs (eg, PARP1 and PARP2) …
Role of nicotinamide adenine dinucleotide and related precursors as therapeutic targets for age-related degenerative diseases: rationale, biochemistry …
Significance: Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide
that serves as an essential cofactor and substrate for a number of critical cellular processes …
that serves as an essential cofactor and substrate for a number of critical cellular processes …
[HTML][HTML] Impaired ribosome biogenesis: mechanisms and relevance to cancer and aging
Z Turi, M Lacey, M Mistrik, P Moudry - Aging (Albany NY), 2019 - ncbi.nlm.nih.gov
The biosynthesis of ribosomes is a complex process that requires the coordinated action of
many factors and a huge energy investment from the cell. Ribosomes are essential for …
many factors and a huge energy investment from the cell. Ribosomes are essential for …
PARPs and ADP-ribosylation in RNA biology: from RNA expression and processing to protein translation and proteostasis
ADP-ribosylation (ADPRylation) is a posttranslational modification of proteins discovered
nearly six decades ago, but many important questions remain regarding its molecular …
nearly six decades ago, but many important questions remain regarding its molecular …
Contributions of DNA damage to Alzheimer's disease
X Lin, A Kapoor, Y Gu, MJ Chow, J Peng… - International journal of …, 2020 - mdpi.com
Alzheimer's disease (AD) is the most common type of neurodegenerative disease. Its typical
pathology consists of extracellular amyloid-β (Aβ) plaques and intracellular tau …
pathology consists of extracellular amyloid-β (Aβ) plaques and intracellular tau …
[HTML][HTML] Poly (ADP-Ribose) polymerase 1 and parthanatos in neurological diseases: From pathogenesis to therapeutic opportunities
X Xu, B Sun, C Zhao - Neurobiology of Disease, 2023 - Elsevier
Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) is the most extensively studied member
of the PARP superfamily, with its primary function being the facilitation of DNA damage …
of the PARP superfamily, with its primary function being the facilitation of DNA damage …
The complex mechanisms by which neurons die following DNA damage in neurodegenerative diseases
Human cells are exposed to numerous exogenous and endogenous insults every day.
Unlike other molecules, DNA cannot be replaced by resynthesis, hence damage to DNA can …
Unlike other molecules, DNA cannot be replaced by resynthesis, hence damage to DNA can …
Epigenome signatures landscaped by histone H3K9me3 are associated with the synaptic dysfunction in Alzheimer's disease
The pathogenesis of Alzheimer's disease (AD) and the commonest cause of dementia in the
elderly remain incompletely understood. Recently, epigenetic modifications have been …
elderly remain incompletely understood. Recently, epigenetic modifications have been …
The nucleolus and PARP1 in cancer biology
M Engbrecht, A Mangerich - Cancers, 2020 - mdpi.com
The nucleolus has been known for a long time to fulfill crucial functions in ribosome
biogenesis, of which cancer cells can become addicted to in order to produce sufficient …
biogenesis, of which cancer cells can become addicted to in order to produce sufficient …
Regulation of biomolecular condensates by Poly (ADP-ribose)
Biomolecular condensates are reversible compartments that form through a process called
phase separation. Post-translational modifications like ADP-ribosylation can nucleate the …
phase separation. Post-translational modifications like ADP-ribosylation can nucleate the …