Adoptive T-cell therapy can involve donor lymphocyte infusion after allogeneic
hematopoietic stem cell transplantation, the administration of tumor infiltrating lymphocyte …

Tumors originate from a number of genetic events that deregulate homeostatic mechanisms
controlling normal cell behavior. The immune system, devoted to patrol the organism against …

Memory stem T cells (TSCM) have been proposed as key determinants of immunologic
memory. However, their exact contribution to a mounting immune response, as well as the …

While opening new frontiers for the cure of malignant and non-malignant diseases, the
increasing use of cell therapy poses also several new challenges related to the safety of a …

Abstract The European Hematology Association (EHA) Roadmap for European Hematology
Research highlights major achievements in diagnosis and treatment of blood disorders and …

A successful strategy in regenerative medicine over the last decade has been the translation
of stem cell therapy to repair diseased or damaged tissue in a wide range of indications …

Transfer of T-cell receptors (TCRs) specific for tumor-associated antigens is a promising
approach for cancer immunotherapy. We developed the TCR gene editing technology that is …

Tristetraprolin (TTP) is an inducible, tandem zinc-finger mRNA binding protein that binds to
adenylate-uridylate–rich elements (AREs) in the 3′-untranslated regions (3′ UTRs) of …

Excitement in the field of tumor immunotherapy is being driven by several remarkable
breakthroughs in recent years. This review will cover recent advances in cancer …

Abstract Graft-versus-tumor (GVT) reactivity mediated by donor T cells in the context of
allogeneic stem cell transplantation (alloSCT) is one of the most potent forms of cellular …