[HTML][HTML] Host genetic regulation of human gut microbial structural variation

DV Zhernakova, D Wang, L Liu, S Andreu-Sánchez… - Nature, 2024 - nature.com
Although the impact of host genetics on gut microbial diversity and the abundance of specific
taxa is well established,,,,–, little is known about how host genetics regulates the genetic …

Winds of change a tale of: asthma and microbiome

D Galeana-Cadena, IA Gómez-García… - Frontiers in …, 2023 - frontiersin.org
The role of the microbiome in asthma is highlighted, considering its influence on immune
responses and its connection to alterations in asthmatic patients. In this context, we review …

Limosilactobacillus reuteri in immunomodulation: molecular mechanisms and potential applications

Z Luo, A Chen, A Xie, X Liu, S Jiang, R Yu - Frontiers in Immunology, 2023 - frontiersin.org
Frequent use of hormones and drugs may be associated with side-effects. Recent studies
have shown that probiotics have effects on the prevention and treatment of immune-related …

Causal associations and shared genetics between hypertension and COVID‐19

A Baranova, H Cao, F Zhang - Journal of Medical Virology, 2023 - Wiley Online Library
To evaluate the genetic relationship between hypertension and COVID‐19 and explore the
molecular pathways linking hypertension to COVID‐19. We performed genetic correlation …

RSV and rhinovirus increase pneumococcal carriage acquisition and density, whereas nasal inflammation is associated with bacterial shedding

E Mitsi, E Nikolaou, A Goncalves, A Blizard, H Hill… - Cell host & …, 2024 - cell.com
Epidemiological studies report the impact of co-infection with pneumococcus and respiratory
viruses upon disease rates and outcomes, but their effect on pneumococcal carriage …

Noninvasive assessment of organ-specific and shared pathways in multi-organ fibrosis using T1 mapping

V Nauffal, MDR Klarqvist, MC Hill, DF Pace… - Nature Medicine, 2024 - nature.com
Fibrotic diseases affect multiple organs and are associated with morbidity and mortality. To
examine organ-specific and shared biologic mechanisms that underlie fibrosis in different …

Incidence rates of childhood asthma with recurrent exacerbations in the US Environmental influences on Child Health Outcomes (ECHO) program

RL Miller, H Schuh, A Chandran, IM Aris… - Journal of Allergy and …, 2023 - Elsevier
Background Descriptive epidemiological data on incidence rates (IRs) of asthma with
recurrent exacerbations (ARE) are sparse. Objectives This study hypothesized that IRs for …

Asthma development is associated with low mucosal IL‐10 during viral infections in early life

ME Melgaard, SK Jensen, A Eliasen, CET Pedersen… - Allergy, 2024 - Wiley Online Library
Background Viral infection is a common trigger of severe respiratory illnesses in early life
and a risk factor for later asthma development. The mechanism leading to asthma could …

Genome-wide study of early and severe childhood asthma identifies interaction between CDHR3 and GSDMB

AU Eliasen, CET Pedersen, MA Rasmussen… - Journal of Allergy and …, 2022 - Elsevier
Background Asthma with severe exacerbation is one of the most common causes of
hospitalization among young children. Exacerbations are typically triggered by respiratory …

Key risk factors of asthma-like symptoms are mediated through infection burden in early childhood

JN Kyvsgaard, N Brustad, LM Hesselberg… - Journal of Allergy and …, 2024 - Elsevier
Background Risk factors of asthma-like symptoms in childhood may act through an
increased infection burden because infections often trigger these symptoms. Objective We …