There are four members of the JAK family and seven of the STAT family in mammals. The
JAK/STAT molecular pathway could be activated by broad hormones, cytokines, growth …

Heart failure is a highly morbid and mortal clinical condition that represents the last stage of
most cardiovascular disorders. Diabetes is strongly associated with an increased incidence …

Background: A key cause of the high mortality of cardiovascular diseases is the
cardiomyocyte inability to renew after cardiac injury. As a promising strategy to supplement …

Although there is a correlation between hypertension and levels of interleukin (IL) 6, the
exact role this cytokine plays in myocardial remodeling is unknown. This is complicated by …

Maximizing baseline function of human pluripotent stem cell-derived cardiomyocytes (hPSC-
CMs) is essential for their effective application in models of cardiac toxicity and disease …

Metabolic disorders such as obesity, insulin resistance and type 2 diabetes mellitus are all
linked to cardiovascular diseases such as cardiac hypertrophy and heart failure. Diabetic …

Circulating levels of interleukin (IL)–6 and related cytokines are elevated in patients with
congestive heart failure and after myocardial infarction. Serum IL-6 concentrations are …

The cardiac fibroblast is a remarkably versatile cell type that coordinates inflammatory,
fibrotic and hypertrophic responses in the heart through a complex array of intracellular and …

Aims Nuclear factor-κB (NF-κB) is a transcription factor induced by a wide range of stimuli,
including hyperglycaemia and pro-inflammatory cytokines. It is associated with cardiac …

Pathological cardiac hypertrophy is a key risk factor for the development of heart failure and
predisposes individuals to cardiac arrhythmia and sudden death. While physiological …