In this review, we first provide a brief historical perspective, discussing how peripheral nerve
injury (PNI) may have caused World War I. We then consider the initiation, progression, and …

Whereas the central nervous system (CNS) usually cannot regenerate, peripheral nerves
regenerate spontaneously after injury because of a permissive environment and activation …

The molecular mechanism underlying brain regeneration in vertebrates remains elusive. We
performed spatial enhanced resolution omics sequencing (Stereo-seq) to capture spatially …

Context Our genome adapts to environmental influences, in part through epigenetic
mechanisms, including DNA methylation. Variations in the quality of the early environment …

Peripheral axons of dorsal root ganglion (DRG) neurons, but not their central axons in the
dorsal columns, regenerate after injury. However, if the neurons are conditioned by a …

Axoplasmic proteins containing nuclear localization signals (NLS) signal retrogradely by an
unknown mechanism in injured nerve. Here we demonstrate that the importin/karyopherin α …

Peripheral nerves regenerate following injury due to the effective activation of the intrinsic
growth capacity of the neurons and the formation of a permissive pathway for outgrowth due …

Neuronal morphological differentiation is regulated by numerous polypeptide growth factors
(neurotrophic factors). Recently, significant progress has been achieved in clarifying the …

The formation of axons and dendrites and maintenance of the neuron's vastly expanded
surface require the continuous addition of new membrane. This is achieved by membrane …

Sensory axons in the adult spinal cord do not regenerate after injury. This is essentially
because of inhibitory components in the damaged CNS, such as myelin-associated …