Atherosclerosis is a chronic inflammatory disease of the arterial wall and the primary
underlying cause of cardiovascular disease. Data from in vivo imaging, cell-lineage tracing …

The immunopathogenesis of rheumatoid arthritis (RA) spans decades, beginning with the
production of autoantibodies against post-translationally modified proteins (checkpoint 1) …

Rationale: Atherosclerotic lesions are known for their cellular heterogeneity, yet the
molecular complexity within the cells of human plaques has not been fully assessed …

T cell ageing has a pivotal role in rendering older individuals vulnerable to infections and
cancer and in impairing the response to vaccination. Easy accessibility to peripheral human …

Well into the 21st century, we still triage acute myocardial infarction on the basis of the
presence or absence of ST-segment elevation, a century-old technology. Meanwhile, we …

Inflammatory processes are firmly established as central to the development and
complications of cardiovascular diseases. Elevated levels of inflammatory markers have …

Age-related T cell dysfunction can lead to failure of immune tolerance mechanisms, resulting
in aberrant T cell-driven cytokine and cytotoxic responses that ultimately cause tissue …

Beginning with the sixth decade of life, the human immune system undergoes dramatic
aging-related changes, which continuously progress to a state of immunosenescence. The …

For> 50 years, it has been recognized that immunity contributes to hypertension. Recent
data have defined an important role of T cells and various T cell–derived cytokines in …

Telomeres are the heterochromatic repeat regions at the ends of eukaryotic chromosomes,
whose length is considered to be a determinant of biological ageing. Normal ageing itself is …