Abstract γδ T cells are a unique and conserved population of lymphocytes that have been
the subject of a recent explosion of interest owing to their essential contributions to many …

Abstract γδ T cells have several innate cell-like features that allow their early activation
following recognition of conserved stress-induced ligands. Here we review recent …

Abstract γδ T cells are considered to be innate-like lymphocytes that respond rapidly to
stress without clonal selection and differentiation. Here we use next-generation sequencing …

Abstract γδ T cells remain an enigma. They are capable of generating more unique antigen
receptors than αβ T cells and B cells combined, yet their repertoire of antigen receptors is …

▪ Abstract While still incomplete, the first data concerning the biochemistry of T cell receptor–
ligand interactions in cell-free systems seem to have considerable predictive value …

The tripartite subdivision of lymphocytes into B cells, αβ T cells, and γδ cells has been
conserved seemingly since the emergence of jawed vertebrates, more than 450 million …

Human Vγ2Vδ2+ T cells recognize mycobacterial non-peptide antigens, such as isopentenyl
pyrophosphate, and their synthetic analogs, such as monoethyl phosphate, through a TCR …

Because of its location and function, the liver is continuously exposed to a large antigenic
load that includes pathogens, toxins, tumor cells and harmless dietary antigens. The range …

Although T cells bearing gamma delta T-cell receptors have long been known to be present
in the epithelial lining of many organs, their specificity and function remain elusive. In the …

Approximately 4% of peripheral blood T cells in humans express a T cell receptor with
markedly restricted germline gene segment usage (Vγ2Vδ2). Remarkably, these T cells …