The skin is the largest barrier organ of the human body and serves to protect the internal
structure of the body from the harmful environment. The epidermis forms the outermost layer …

Psoriasis (Ps) and psoriatic arthritis (PsA) are genetically complex diseases with strong
genetic evidence. Recently, susceptibility genes for Ps and PsA have been identified within …

Purpose: To identify the tumor portrait of the minority of head and neck squamous cell
carcinoma (HNSCC) patients with recurrent–metastatic (RM) disease who upon treatment …

Since the emergence of proteomics methods, many proteins specific for renal cell carcinoma
(RCC) have been identified. Despite their usefulness for the specific diagnosis of RCC, such …

The identification of new genes/proteins involved in breast cancer (BC) occurrence is widely
used to discover novel biomarkers and understand the molecular mechanisms of BC …

Abstract Calprotectin (S100A8/A9), a heterodimeric protein complex of calcium-binding
proteins S100A8 and S100A9, plays key roles in cell cycle regulation and inflammation, with …

S100A2, a member of the S100 protein family, is known to be downregulated in a number of
human cancers, leading to its designation as a potential tumor suppressor gene. Here, we …

Background: It is assumed that beside alterations in the filaggrin gene (FLG), disturbances
within genes encoding other cornified envelope proteins are also involved in atopic …

Abstract Cysteine-rich C-terminal 1 (CRCT1) is encoded by the epidermal differentiation
complex (EDC), a gene cluster that was recently linked to esophageal cancer. However, the …

Objective: ZNF750, a transcriptional regulator of epidermal differentiation, has been
identified as a tumor suppressor in esophageal squamous cell carcinoma (ESCC). The aim …