Cachexia is the involuntary loss of muscle and adipose tissue that strongly affects mortality
and treatment efficacy in patients with cancer or chronic inflammatory disease. Currently, no …

Muscle RING finger 1 (MuRF1) and muscle atrophy F-box (MAFbx)/atrogin-1 were identified
more than 10 years ago as two muscle-specific E3 ubiquitin ligases that are increased …

Introduction Fibrosis, or scar formation, is a pathological condition characterized by
excessive production and accumulation of collagen, loss of tissue architecture, and organ …

The E3 ubiquitin ligase MuRF1/TRIM63 was identified 20 years ago and suspected to play
important roles during skeletal muscle atrophy. Since then, numerous studies have been …

Macrophage phagocytosis of particles and pathogens is an essential aspect of innate host
defense. Phagocytic function requires cytoskeletal rearrangements that depend on the …

Glucocorticoids are known to regulate protein metabolism in skeletal muscle, producing a
catabolic effect that is opposite that of insulin. In many catabolic diseases, such as sepsis …

In this review we summarize recent major advances in our understanding on the molecular
mechanisms, mediators, and biomarkers of acute lung injury (ALI) and alveolar-capillary …

Cachexia and muscle wasting are well recognized as common and partly reversible features
of chronic obstructive pulmonary disease (COPD), adversely affecting disease progression …

Skeletal muscle wasting contributes to impaired exercise capacity, reduced health-related
quality of life and is an independent determinant of mortality in chronic obstructive …

Survival from critical illness has improved in recent years, leading to increased attention to
the sequelae of such illness. Neuromuscular weakness in the intensive care unit (ICU) is …