Importance Survival from sepsis has improved in recent years, resulting in an increasing
number of patients who have survived sepsis treatment. Current sepsis guidelines do not …

Risk of MI after Acute Infection Among patients who are hospitalized for pneumococcal
pneumonia, the incidence of myocardial infarction is 7 to 8%. The true incidence of …

Background The global burden of sepsis is estimated as 15 to 19 million cases annually,
with a mortality rate approaching 60% in low-income countries. Methods In this retrospective …

Objective To identify research priorities in the management, epidemiology, outcome and
underlying causes of sepsis and septic shock. Design A consensus committee of 16 …

Objectives: To describe, with an emphasis on clinical applications, what is known about the
pathophysiology, management, and implications of septic cardiomyopathy in the adult ICU …

Rationale: Sepsis induces a sustained immune dysfunction responsible for poor outcome
and nosocomial infections. Myeloid-derived suppressor cells (MDSCs) described in cancer …

Sepsis is a devastating disease that carries an enormous toll in terms of human suffering
and lives lost. Over 100 novel pharmacologic agents that targeted specific molecules or …

Background: The excess risk of cardiovascular disease associated with a wide array of
infectious diseases is unknown. We quantified the short-and long-term risk of major …

Innate immune cells can develop exacerbated immunologic response and long-term
inflammatory phenotype following brief exposure to endogenous or exogenous insults …

Sepsis is life-threating organ dysfunction due to infection. Incidence of sepsis is increasing
and the short-term mortality is improving, generating more sepsis survivors. These sepsis …