[HTML][HTML] Malaria vaccines since 2000: progress, priorities, products

PE Duffy, J Patrick Gorres - npj Vaccines, 2020 - nature.com
Malaria vaccine development entered a new era in 2015 when the pre-erythrocytic
Plasmodium falciparum candidate RTS, S was favorably reviewed by the European …

[HTML][HTML] Malaria vaccines: the 60-year journey of hope and final success—lessons learned and future prospects

AA El-Moamly, MA El-Sweify - Tropical Medicine and Health, 2023 - Springer
Background The world has made great strides towards beating malaria, although about half
of the world population is still exposed to the risk of contracting malaria. Developing an …

Vaccination with Plasmodium vivax Duffy-binding protein inhibits parasite growth during controlled human malaria infection

MM Hou, JR Barrett, Y Themistocleous… - Science translational …, 2023 - science.org
There are no licensed vaccines against Plasmodium vivax. We conducted two phase 1/2a
clinical trials to assess two vaccines targeting P. vivax Duffy-binding protein region II …

PRIMVAC vaccine adjuvanted with Alhydrogel or GLA-SE to prevent placental malaria: a first-in-human, randomised, double-blind, placebo-controlled study

SB Sirima, L Richert, A Chêne, AT Konate… - The Lancet Infectious …, 2020 - thelancet.com
Background PRIMVAC is a VAR2CSA-derived placental malaria vaccine candidate aiming
to prevent serious clinical outcomes of Plasmodium falciparum infection during pregnancy …

The immunology of Plasmodium vivax malaria

LR Antonelli, C Junqueira, JM Vinetz… - Immunological …, 2020 - Wiley Online Library
Plasmodium vivax infection, the predominant cause of malaria in Asia and Latin America,
affects~ 14 million individuals annually, with considerable adverse effects on wellbeing and …

[HTML][HTML] Plasmodium vivax vaccine: What is the best way to go?

GTS Veiga, MR Moriggi, JF Vettorazzi… - Frontiers in …, 2023 - frontiersin.org
Malaria is one of the most devastating human infectious diseases caused by Plasmodium
spp. parasites. A search for an effective and safe vaccine is the main challenge for its …

[HTML][HTML] Rapid and iterative genome editing in the malaria parasite Plasmodium knowlesi provides new tools for P. vivax research

F Mohring, MN Hart, TA Rawlinson, R Henrici… - Elife, 2019 - elifesciences.org
Tackling relapsing Plasmodium vivax and zoonotic Plasmodium knowlesi infections is
critical to reducing malaria incidence and mortality worldwide. Understanding the biology of …

Diagnosis of Malaria Parasites Plasmodium spp. in Endemic Areas: Current Strategies for an Ancient Disease

B Gitta, N Kilian - BioEssays, 2020 - Wiley Online Library
Fast and effective detection of the causative agent of malaria in humans, protozoan
Plasmodium parasites, is of crucial importance for increasing the effectiveness of treatment …

Vaccines and monoclonal antibodies: new tools for malaria control

K Miura, Y Flores-Garcia, CA Long… - Clinical Microbiology …, 2024 - Am Soc Microbiol
Malaria remains one of the biggest health problems in the world. While significant reductions
in malaria morbidity and mortality had been achieved from 2000 to 2015, the favorable trend …

[HTML][HTML] Controlled human malaria infection with a clone of Plasmodium vivax with high-quality genome assembly

AM Minassian, Y Themistocleous, SE Silk, JR Barrett… - JCI insight, 2021 - ncbi.nlm.nih.gov
Controlled human malaria infection (CHMI) provides a highly informative means to
investigate host-pathogen interactions and enable in vivo proof-of-concept efficacy testing of …