The dominant nature of the Huntington's disease gene mutation has allowed genetic models
to be developed in multiple species, with the mutation causing an abnormal neurological …

Brain development is a highly orchestrated complex process. The developing brain utilizes
many substrates including glucose, ketone bodies, lactate, fatty acids and amino acids for …

Although intravenous delivery of mesenchymal stem cells (MSCs) prepared from adult bone
marrow reduces infarction size and ameliorates functional deficits in rat middle cerebral …

Hypothermia is a standard treatment for neonatal encephalopathy, but nearly 50% of treated
infants have adverse outcomes. Pharmacological therapies can act through complementary …

Insults in the prenatal and early postnatal period increase the risk for behavioral problems
later in life. One hypothesis is that pre-and postnatal stressors influence structural and …

In experimental animal research, a short phylogenetic distance, ie, high resemblance
between the model species and the species to be modeled is expected to increase the …

The purpose of this study was to investigate the clinical role of proton magnetic resonance
spectroscopy (1H-MRS) in the diagnosis of acute cerebral infarction. Using databases …

BACKGROUND AND PURPOSE: As amide proton transfer imaging is sensitive to protein
content and intracellular pH, it has been widely used in the nervous system, including brain …

Purpose This study evaluated the longitudinal metabolic alterations after neonatal hypoxia‐
ischemia (HI) in rats and tested the neuroprotective effect of acetyl‐L‐carnitine (ALCAR) …

Background and purpose Hypoxia and cerebral ischemia (HI) events are capable of
triggering important changes in brain metabolism, including glucose metabolism …