The development of new ion-activation/dissociation methods continues to be one of the most
active areas of mass spectrometry owing to the broad applications of tandem mass …

For about three decades, the chemistry of cation radicals derived from organic molecules
had received a major impetus from mass spectrometry. This was because cation radicals …

The presence of a single d-amino acid in a peptide is very difficult to detect. Mass
spectrometry-based approaches rely on differences in fragmentation between all l-amino …

The low-lying electronic states of Irgacure 2959, a Norrish-type I photoinitiator, complexed
with a single metal cation are investigated in the gas phase by photodissociation action …

Ultraviolet-photodissociation (UVPD) mass spectrometry is an emerging analytical tool for
structural elucidation of biomolecules including lipids. Gas phase UVPD of ionised fatty …

Glycans are fundamental biological macromolecules, yet despite their prevalence and
recognized importance, a number of unique challenges hinder routine characterization. The …

Post-translational modifications that do not result in a change in mass are particularly difficult
to detect by mass spectrometry. For example, isomerization of aspartic acid or epimerization …

Structural characterization of proteins in the gas phase is becoming increasingly popular,
highlighting the need for a greater understanding of how proteins behave in the absence of …

The detection and assignment of protonation isomers, termed protomers, of gas-phase ions
remains a challenge in mass spectrometry. With the emergence of ion-mobility techniques …

Although it is well-known that protein turnover essentially stops in mature lens fiber cells,
mapping out the ensuing protein degradation and its effects on lens function over time …