The Role of Macrophages in Staphylococcus aureus Infection

GR Pidwill, JF Gibson, J Cole, SA Renshaw… - Frontiers in …, 2021 - frontiersin.org
Staphylococcus aureus is a member of the human commensal microflora that exists,
apparently benignly, at multiple sites on the host. However, as an opportunist pathogen it …

Exploring the Role of Staphylococcus aureus in Inflammatory Diseases

H Chen, J Zhang, Y He, Z Lv, Z Liang, J Chen, P Li… - Toxins, 2022 - mdpi.com
Staphylococcus aureus is a very common Gram-positive bacterium, and S. aureus infections
play an extremely important role in a variety of diseases. This paper describes the types of …

Staphylococcus aureus Vaccine Research and Development: The Past, Present and Future, Including Novel Therapeutic Strategies

J Clegg, E Soldaini, RM McLoughlin… - Frontiers in …, 2021 - frontiersin.org
Staphylococcus aureus is one of the most important human pathogens worldwide. Its high
antibiotic resistance profile reinforces the need for new interventions like vaccines in …

Inside job: Staphylococcus aureus host-pathogen interactions

J Horn, K Stelzner, T Rudel, M Fraunholz - International Journal of Medical …, 2018 - Elsevier
Staphylococcus aureus is a notorious opportunistic pathogen causing a plethora of
diseases. Recent research established that once phagocytosed by neutrophils and …

Intracellular replication of Staphylococcus aureus in mature phagolysosomes in macrophages precedes host cell death, and bacterial escape and dissemination

RS Flannagan, B Heit, DE Heinrichs - Cellular microbiology, 2016 - Wiley Online Library
The success of Staphylococcus aureus as a pathogen is partly attributable to its ability to
thwart host innate immune responses, which includes resisting the antimicrobial functions of …

Staphylococcus aureus RNAIII and Its Regulon Link Quorum Sensing, Stress Responses, Metabolic Adaptation, and Regulation of Virulence Gene Expression

D Bronesky, Z Wu, S Marzi, P Walter… - Annual review of …, 2016 - annualreviews.org
Staphylococcus aureus RNAIII is one of the main intracellular effectors of the quorum-
sensing system. It is a multifunctional RNA that encodes a small peptide, and its noncoding …

Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection

AF Brown, AG Murphy, SJ Lalor, JM Leech… - PLoS …, 2015 - journals.plos.org
Mechanisms of protective immunity to Staphylococcus aureus infection in humans remain
elusive. While the importance of cellular immunity has been shown in mice, T cell responses …

In or out: Phagosomal escape of Staphylococcus aureus

A Moldovan, MJ Fraunholz - Cellular microbiology, 2019 - Wiley Online Library
Staphylococcus aureus is internalised by host cells in vivo, and recent research results
suggest that the bacteria use this intracellularity to persist in the host and form a reservoir for …

Antibody–antibiotic conjugates: a novel therapeutic platform against bacterial infections

S Mariathasan, MW Tan - Trends in molecular medicine, 2017 - cell.com
Antibodies are potent components of the immune repertoire and have been successfully
exploited to treat bacterial infections. Recently an antibody–antibiotic conjugate (AAC) that …

The beclin 1 interactome: Modification and roles in the pathology of autophagy-related disorders

S Kaur, H Changotra - Biochimie, 2020 - Elsevier
Beclin 1 a yeast Atg6/VPS30 orthologue has a significant role in autophagy process
(Macroautophagy) and protein sorting. The function of beclin 1 depends on the interaction …