Increasing evidence from epidemiological, clinical and experimental studies indicate that
age-related cerebromicrovascular dysfunction and microcirculatory damage play critical …

Background and Purpose—This scientific statement provides an overview of the evidence
on vascular contributions to cognitive impairment and dementia. Vascular contributions to …

Functional magnetic resonance imaging (fMRI) provides a unique view of the working
human mind. The blood-oxygen-level-dependent (BOLD) signal, detected in fMRI, reflects …

Human brain functional networks contain a few densely connected hubs that play a vital role
in transferring information across regions during resting and task states. However, the …

Brain temperature, as an independent therapeutic target variable, has received increasingly
intense clinical attention. To date, brain hypothermia represents the most potent …

The two major interfaces separating brain and blood have different primary roles. The
choroid plexuses secrete cerebrospinal fluid into the ventricles, accounting for most net fluid …

According to Alzheimer's Disease International, 55 million people worldwide are living with
dementia. Dementia is a disorder that manifests as a set of related symptoms, which usually …

There is increasing evidence that cerebrovascular dysfunction plays a role not only in
vascular causes of cognitive impairment but also in Alzheimer's disease (AD). Vascular risk …

Cerebrovascular reactivity is the change in cerebral blood flow in response to a vasodilatory
or vasoconstrictive stimulus. Measuring variations of cerebrovascular reactivity between …

Opioid drugs are important tools to alleviate pain of different origins, but they have strong
addictive potential and their abuse at higher doses often results in serious health …