In recent years, animal models in psychiatric research have been criticized for their limited
translational value to the clinical situation. Failures in clinical trials have thus often been …

One of the major risk factors for global death and disability is alcohol, tobacco, and illicit drug
use. While there is increasing knowledge with respect to individual factors promoting the …

Alcohol-dependent patients commonly show impairments in executive functions that
facilitate craving and can lead to relapse. However, the molecular mechanisms leading to …

A major hypothesis in addiction research is that alcohol induces neuroadaptations in the
mesolimbic dopamine (DA) system and that these neuroadaptations represent a key …

Chronic alcohol consumption and withdrawal leads to anxiety, escalated alcohol drinking
behavior, and alcohol dependence. Alterations in the function of key structures within the …

Excessive alcohol use is the cause of an ongoing public health crisis, and accounts for~ 5%
of global disease burden. A minority of people with recreational alcohol use develop alcohol …

Alcoholism, or alcohol use disorder, is a major public health concern that is a considerable
risk factor for morbidity and disability; therefore, effective treatments are urgently needed …

Loss of control over drinking is a key deficit in alcoholism causally associated with
malfunction of the medial prefrontal cortex (mPFC), but underlying molecular and cellular …

Individuals diagnosed with anxiety‐related illnesses are at increased risk of developing
alcoholism, exhibit a telescoped progression of this disease and fare worse in recovery …

Approved pharmacological treatments for alcohol use disorder are limited in their
effectiveness, and new drugs that can easily be translated into the clinic are warranted. One …