Supramolecular hydrogels with tunable chirality for promising biomedical applications

X Dou, N Mehwish, C Zhao, J Liu, C Xing… - Accounts of Chemical …, 2020 - ACS Publications
Conspectus Chirality exits from molecular-level, supramolecular, and nanoscaled helical
structures to the macroscopic level in biological life. Among these various levels, as the …

[HTML][HTML] Phage display derived peptides for Alzheimer's disease therapy and diagnosis

X Zhang, X Zhang, H Gao, G Qing - Theranostics, 2022 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is an incurable and fatal progressive neurodegenerative disorder
associated with memory and cognition impairment. AD is one of the top medical care …

[HTML][HTML] Chiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of Alzheimer's disease

K Hou, J Zhao, H Wang, B Li, K Li, X Shi, K Wan… - Nature …, 2020 - nature.com
Preventing aggregation of amyloid beta (Aβ) peptides is a promising strategy for the
treatment of Alzheimer's disease (AD), and gold nanoparticles have previously been …

Chiral‐Selective Antigen‐Presentation by Supramolecular Chiral Polymer Micelles

H Jiang, R Liu, L Wang, X Wang, M Zhang… - Advanced …, 2023 - Wiley Online Library
Chirality is ubiquitous in biological systems, which is closely related to biological functions,
life processes, and even the pathogenesis of diseases. However, the interface between the …

Gold nanoclusters for Parkinson's disease treatment

G Gao, R Chen, M He, J Li, L Wang, T Sun - Biomaterials, 2019 - Elsevier
Drug discovery for Parkinson's disease (PD) is challenging. Here we report that gold
nanoclusters (AuNCs) can serve as a novel candidate for the design of anti-PD drugs. With …

Chirality-selected chemical modulation of amyloid aggregation

N Gao, Z Du, Y Guan, K Dong, J Ren… - Journal of the American …, 2019 - ACS Publications
Due to the composed α-helical/β-strand structures, β-amyloid peptide (Aβ) is sensitive to
chiral environments. The orientation and chirality of the Aβ strand strongly influence its …

Opening lids: modulation of lipase immobilization by graphene oxides

M Mathesh, B Luan, TO Akanbi, JK Weber, J Liu… - Acs …, 2016 - ACS Publications
Lipases, which can be immobilized and reused for many reaction cycles, are important
enzymes with many industrial applications. A key challenge in lipase immobilization for …

The size-effect of gold nanoparticles and nanoclusters in the inhibition of amyloid-β fibrillation

G Gao, M Zhang, D Gong, R Chen, X Hu, T Sun - Nanoscale, 2017 - pubs.rsc.org
A significant pathological signature of Alzheimer's disease (AD) is the deposition of amyloid-
β (Aβ) plaques in the brain and the synaptic dysfunction and neurodegeneration associated …

Chiral graphene materials for enantiomer separation

Q Cheng, H Pei, Q Ma, R Guo, N Liu, Z Mo - Chemical Engineering Journal, 2023 - Elsevier
Chirality is an interesting natural property and has a special status in living organisms. Pure
enantiomers have a very important role in biological health and safety. Enantiomer …

Probing adsorption behaviors of BSA onto chiral surfaces of nanoparticles

X Wang, X Wang, M Wang, D Zhang, Q Yang, T Liu… - Small, 2018 - Wiley Online Library
Chiral properties of nanoscale materials are of importance as they dominate interactions
with proteins in physiological environments; however, they have rarely been investigated. In …