Sigma receptor (σR) ligands have proven to be useful as cancer diagnostics and anticancer
therapeutics and their ligands have been developed as molecular probes in oncology …

Introduction: Sigma receptors are involved in several central nervous system (CNS)
disorders, including mood disorders (depression and anxiety), psychosis, schizophrenia …

Two problems that have hampered a receptor research are (i) a lack of high-affinity agents
and (ii) the recent identification of multiple populations of a receptors (ie, a\and< 72 sites) …

The invention relates to methods for the treatment of central nervous system disorders,
gastrointestinal disorders, drug abuse, angina, migraine, hypertension and depression by …

The monoamine oxidase (MAO) inhibitory properties of a series of amphetamine derivatives
with different substituents at or around the para position of the aromatic ring were evaluated …

The optical antipodes of iV-allyl-N-normetazocine (2; SKF 10047, NANM) were the original
compounds used for the classification of the a receptor as distinct from otherreceptors such …

(01)= 1.5 nM, 1050 (02)= 0.07 nM). Introduction of substituents in the benzene ring of the
spiro [isobenzofuran-l (3iT), 4'-piperidine] ring system of Lu 28-179 mainly affects affinity for …

Sigma receptors (σ-1 and σ-2) are non-opioid proteins implicated in the pathophysiology of
various neurological disorders and cancer. The σ-1 subtype is a chaperon protein widely …

The invention relates to methods for the treatment of central nervous system disorders,
neurological disorders, gas trointestinal disorders, drug abuse, angina, migraine, hyper …

A set of the title compounds having different substituents (R1, R2) on their phenyl groups
was synthesized to find σ receptor binding affinity. Among the compounds, 2b (R1 R2 Cl) …