[HTML][HTML] PRC2, chromatin regulation, and human disease: insights from molecular structure and function
X Liu, X Liu - Frontiers in Oncology, 2022 - frontiersin.org
Polycomb repressive complex 2 (PRC2) is a multisubunit histone-modifying enzyme
complex that mediates methylation of histone H3 lysine 27 (H3K27). Trimethylated H3K27 …
complex that mediates methylation of histone H3 lysine 27 (H3K27). Trimethylated H3K27 …
DNA binding by polycomb-group proteins: searching for the link to CpG islands
BM Owen, C Davidovich - Nucleic Acids Research, 2022 - academic.oup.com
Polycomb group proteins predominantly exist in polycomb repressive complexes (PRCs)
that cooperate to maintain the repressed state of thousands of cell-type-specific genes …
that cooperate to maintain the repressed state of thousands of cell-type-specific genes …
[HTML][HTML] PRC2. 1-and PRC2. 2-specific accessory proteins drive recruitment of different forms of canonical PRC1
Summary Polycomb repressive complex 2 (PRC2) mediates H3K27me3 deposition, which is
thought to recruit canonical PRC1 (cPRC1) via chromodomain-containing CBX proteins to …
thought to recruit canonical PRC1 (cPRC1) via chromodomain-containing CBX proteins to …
[HTML][HTML] Oncohistone interactome profiling uncovers contrasting oncogenic mechanisms and identifies potential therapeutic targets in high grade glioma
R Siddaway, L Canty, S Pajovic, S Milos, E Coyaud… - Acta …, 2022 - Springer
Histone H3 mutations at amino acids 27 (H3K27M) and 34 (H3G34R) are recurrent drivers
of pediatric-type high-grade glioma (pHGG). H3K27M mutations lead to global disruption of …
of pediatric-type high-grade glioma (pHGG). H3K27M mutations lead to global disruption of …
[HTML][HTML] Evolutionary adaptation of the Polycomb repressive complex 2
S Fischer, LM Weber, R Liefke - Epigenetics & Chromatin, 2022 - Springer
The Polycomb repressive complex 2 (PRC2) is an essential chromatin regulatory complex
involved in repressing the transcription of diverse developmental genes. PRC2 consists of a …
involved in repressing the transcription of diverse developmental genes. PRC2 consists of a …
[HTML][HTML] Inseparable RNA binding and chromatin modification activities of a nucleosome-interacting surface in EZH2
EH Gail, E Healy, SF Flanigan, N Jones, XH Ng… - Nature Genetics, 2024 - nature.com
Abstract Polycomb repressive complex 2 (PRC2) interacts with RNA in cells, but there is no
consensus on how RNA regulates PRC2 canonical functions, including chromatin …
consensus on how RNA regulates PRC2 canonical functions, including chromatin …
[HTML][HTML] Polycomb repressive complex 2 accessory factors: rheostats for cell fate decision?
Highlights•Various partner proteins associate sub-stoichiometrically, impacting PRC2
activities.•Distinctive PRC2 subcomplexes form in tissue-specific and spatiotemporal …
activities.•Distinctive PRC2 subcomplexes form in tissue-specific and spatiotemporal …
Structural basis for inactivation of PRC2 by G-quadruplex RNA
J Song, AR Gooding, WO Hemphill, BD Love… - Science, 2023 - science.org
Polycomb repressive complex 2 (PRC2) silences genes through trimethylation of histone
H3K27. PRC2 associates with numerous precursor messenger RNAs (pre-mRNAs) and …
H3K27. PRC2 associates with numerous precursor messenger RNAs (pre-mRNAs) and …
[HTML][HTML] H2a ubiquitination alters H3-tail dynamics on linker-DNA to enhance H3K27 methylation
H Ohtomo, S Ito, NJ McKenzie, M Uckelmann… - Journal of Molecular …, 2023 - Elsevier
Abstract Polycomb repressive complex 1 (PRC1) and PRC2 are responsible for epigenetic
gene regulation. PRC1 ubiquitinates histone H2A (H2Aub), which subsequently promotes …
gene regulation. PRC1 ubiquitinates histone H2A (H2Aub), which subsequently promotes …
Epigenetic regulation of embryonic ectoderm development in stem cell differentiation and transformation during ontogenesis
L Huang, F Li, L Ye, F Yu, C Wang - Cell Proliferation, 2023 - Wiley Online Library
Dynamic chromatin accessibility regulates stem cell fate determination and tissue
homeostasis via controlling gene expression. As a histone‐modifying enzyme that …
homeostasis via controlling gene expression. As a histone‐modifying enzyme that …