A fine-tuned activation and deactivation of proteases and their inhibitors are involved in the
execution of the inflammatory response. The zymogen/proenzyme plasminogen is converted …

The oral cavity is a unique environment that consists of teeth surrounded by periodontal
tissues, oral mucosae with minor salivary glands, and terminal parts of major salivary glands …

Gastric cancer (GC) is the most common gastrointestinal malignant tumor, and distant
metastasis is a critical factor in the prognosis of patients with GC. Understanding the …

Myocardial infarction and ischemic stroke are the most frequent causes of death or disability
worldwide. Due to their ability to dissolve blood clots, the thrombolytics are frequently used …

Fibrinolytic factors like plasminogen, tissue-type plasminogen activator (tPA), and urokinase
plasminogen activator (uPA) dissolve clots. Though mere extracellular-matrix-degrading …

Background Emerging evidence has highlighted the importance of extracellular vesicle (EV)-
based biomarkers of resistance to immunotherapy with checkpoint inhibitors in metastatic …

Background Increased levels of plasminogen activator inhibitor-1 (PAI-1) in tumors have
been found to correlate with poor clinical outcomes in patients with cancer. Although …

Severe injuries, such as burns, provoke a systemic inflammatory response syndrome (SIRS)
that imposes pathology on all organs. Simultaneously, severe injury also elicits activation of …

Diltiazem and glibenclamide are commonly used hypotensive and antidiabetic drugs. This
study reports the discovery of the potential antitumor and antimetastatic effects of these two …

Adhesive small bowel obstruction remains a common problem for surgeons. After surgery,
platelet aggregation contributes to coagulation cascade and fibrin clot formation. With …