Bradykinin is a peptide implicated in inflammatory pain in both humans and rodents. In
rodent sensory neurons, activation of B1 and B2 bradykinin receptors induces neuronal …

Many medications commonly used to treat neuropathic pain are associated with significant,
dose-limiting adverse effects, including sedation, dizziness, and fatigue. These adverse …

Activation of cannabinoid receptor type 1 (CB1) produces analgesia in a variety of
preclinical models of pain; however, engagement of central CB1 receptors is accompanied …

Satellite glial cells (SGCs) are a type of glial cell population that originates from neural crest
cells. They ultimately migrate to surround the cell bodies of neurons in the ganglia of the …

Peripheral sensitization of nociceptors is believed to be a key driver of chronic pain states.
Here, we sought to study the effects of a modified version of inflammatory soup on the …

Supportive social environments are known to have an analgesic effect, significantly reducing
the perception of pain. While this effect is recognised, and endogenous pain modulatory …

BACKGROUND: Corticosteroid receptors, including mineralocorticoid receptor (MR) and
glucocorticoid receptor (GR), play important roles in inflammatory pain in the dorsal root …

Background and purpose: In this study, we applied an induced pluripotent stem cell (iPSC)-
based model of inherited erythromelalgia (IEM) to screen a library of 295 small molecules …

Cannabis has been used for thousands of years for recreational and therapeutic effects. The
efficacy of medicinal cannabis for conditions such as epilepsy and pain has resulted in the …

The endocannabinoid system plays an important role in social behaviors across a variety of
species. Recently, the distribution of cannabinoid receptor 1 (CB1) was linked to the mating …