Research priorities for an HIV cure: international AIDS society global scientific strategy 2021
Despite the success of antiretroviral therapy (ART) for people living with HIV, lifelong
treatment is required and there is no cure. HIV can integrate in the host genome and persist …
treatment is required and there is no cure. HIV can integrate in the host genome and persist …
Recommendations for analytical antiretroviral treatment interruptions in HIV research trials—report of a consensus meeting
B Julg, L Dee, J Ananworanich, DH Barouch, K Bar… - The lancet HIV, 2019 - thelancet.com
Analytical antiretroviral treatment interruption (ATI) is an important feature of HIV research,
seeking to achieve sustained viral suppression in the absence of antiretroviral therapy (ART) …
seeking to achieve sustained viral suppression in the absence of antiretroviral therapy (ART) …
HIV rebound is predominantly fueled by genetically identical viral expansions from diverse reservoirs
Viral rebound upon stopping combined antiretroviral therapy poses a major barrier toward
an HIV cure. Cellular and anatomical sources responsible for reinitiating viral replication …
an HIV cure. Cellular and anatomical sources responsible for reinitiating viral replication …
“We need to deploy them very thoughtfully and carefully”: Perceptions of analytical treatment interruptions in HIV cure research in the United States—A qualitative …
K Dubé, D Evans, L Dee, L Sylla, J Taylor… - AIDS Research and …, 2018 - liebertpub.com
Strategies to control HIV in the absence of antiretroviral therapy are needed to cure HIV.
However, such strategies will require analytical treatment interruptions (ATIs) to determine …
However, such strategies will require analytical treatment interruptions (ATIs) to determine …
Novel approaches towards a functional cure of HIV/AIDS
Therapeutic approaches towards a functional cure or eradication of HIV have gained
renewed momentum upon encouraging data emerging from studies in SIV monkey models …
renewed momentum upon encouraging data emerging from studies in SIV monkey models …
Ethics of treatment interruption trials in HIV cure research: addressing the conundrum of risk/benefit assessment
GE Henderson, HL Peay, E Kroon, RJ Cadigan… - Journal of medical …, 2018 - jme.bmj.com
Though antiretroviral therapy is the standard of care for people living with HIV, its treatment
limitations, burdens, stigma and costs lead to continued interest in HIV cure research. Early …
limitations, burdens, stigma and costs lead to continued interest in HIV cure research. Early …
Applying the behavioural and social sciences research (BSSR) functional framework to HIV cure research
K Dubé, JD Auerbach, MJ Stirratt… - African Journal of …, 2019 - journals.lww.com
Introduction: The search for an HIV cure involves important behavioural and social
processes that complement the domains of biomedicine. However, the field has yet to tap …
processes that complement the domains of biomedicine. However, the field has yet to tap …
Ethical and practical considerations for mitigating risks to sexual partners during analytical treatment interruptions in HIV cure-related research
K Dubé, J Kanazawa, L Dee, J Taylor… - HIV research & …, 2021 - Taylor & Francis
Background Background: Analytical treatment interruptions (ATIs) in HIV cure-related
research can result in trial participants becoming viremic with HIV, placing HIV-negative …
research can result in trial participants becoming viremic with HIV, placing HIV-negative …
The significance and expectations of HIV cure research among people living with HIV in Australia
Most people living with HIV (PLHIV) with reliable access to antiretroviral treatment (ART)
have a life expectancy similar to uninfected populations. Despite this, HIV can negatively …
have a life expectancy similar to uninfected populations. Despite this, HIV can negatively …
Perceptions of HIV cure research among people living with HIV in Australia
Participation in HIV cure-related clinical trials that involve antiretroviral treatment (ART)
interruption may pose substantial individual risks for people living with HIV (PLHIV) without …
interruption may pose substantial individual risks for people living with HIV (PLHIV) without …