Oncolytic viruses (OVs) as one promising antitumor methods have made important
contributions to tumor immunotherapy, which arouse increasing attention. They provide the …

Hendra virus and Nipah virus are highly pathogenic paramyxoviruses that have recently
emerged from flying foxes to cause serious disease outbreaks in humans and livestock in …

The transcription factors interferon regulatory factor 3 (IRF3) and NF-κB are required for the
expression of many genes involved in the innate immune response. Viral infection, or the …

Most paramyxoviruses circumvent the IFN response by blocking IFN signaling and limiting
the production of IFN by virus-infected cells. Here we report that the highly conserved …

The replication and pathogenicity of influenza A virus (FLUAV) are controlled in part by the
alpha/beta interferon (IFN-α/β) system. This virus-host interplay is dependent on the …

Nuclear receptors (NRs) repress transcriptional responses to diverse signaling pathways as
an essential aspect of their biological activities, but mechanisms determining the specificity …

The Ebola virus VP35 protein was previously found to act as an interferon (IFN) antagonist
which could complement growth of influenza delNS1 virus, a mutant influenza virus lacking …

The type I IFN-α/β gene family was identified about a quarter of a century ago as a prototype
of many cytokine gene families, which led to the subsequent burst of studies on molecular …

The objective of this study was to examine the expression of toll‐like receptors (TLRs) by the
uterine epithelial cell line ECC‐1 and to determine if stimulation of the expressed TLRs …

Abstract Double-stranded RNA (dsRNA), a frequent byproduct of virus infection, is
recognized by Toll-like receptor 3 (TLR3) to mediate innate immune response to virus …