Effect of anesthesia on the developing brain: infant and fetus
DB Andropoulos - Fetal diagnosis and therapy, 2018 - karger.com
The potential for commonly used anesthetics and sedatives to cause neuroapoptosis and
other neurodegenerative changes in the developing mammalian brain has become evident …
other neurodegenerative changes in the developing mammalian brain has become evident …
The potential role of dexmedetomidine on neuroprotection and its possible mechanisms: Evidence from in vitro and in vivo studies
K Unchiti, P Leurcharusmee… - European Journal of …, 2021 - Wiley Online Library
Neurological disorders following brain injuries and neurodegeneration are on the rise
worldwide and cause disability and suffering in patients. It is crucial to explore novel …
worldwide and cause disability and suffering in patients. It is crucial to explore novel …
Randomized clinical trial of intraoperative dexmedetomidine to prevent delirium in the elderly undergoing major non-cardiac surgery
CJ Li, BJ Wang, DL Mu, J Hu, C Guo… - Journal of British …, 2020 - academic.oup.com
Background Delirium is common in elderly patients after surgery and is associated with poor
outcomes. This study aimed to investigate the impact of intraoperative dexmedetomidine on …
outcomes. This study aimed to investigate the impact of intraoperative dexmedetomidine on …
Do anesthetics harm the developing human brain? An integrative analysis of animal and human studies
EP Lin, JR Lee, CS Lee, M Deng, AW Loepke - Neurotoxicology and …, 2017 - Elsevier
Anesthetics that permit surgical procedures and stressful interventions have been found to
cause structural brain abnormalities and functional impairment in immature animals …
cause structural brain abnormalities and functional impairment in immature animals …
[HTML][HTML] Dexmedetomidine for the prevention of postoperative delirium in elderly patients undergoing noncardiac surgery: a meta-analysis of randomized controlled …
H Zeng, Z Li, J He, W Fu - PLoS One, 2019 - journals.plos.org
Background Postoperative delirium (POD) among the elderly population that undergoes
noncardiac surgery is significantly associated with adverse clinical outcomes. We conducted …
noncardiac surgery is significantly associated with adverse clinical outcomes. We conducted …
Recent insights into molecular mechanisms of propofol-induced developmental neurotoxicity: implications for the protective strategies
November 2016• Volume 123• Number 5 www. anesthesia-analgesia. org 1287 induction
and maintenance of anesthesia and procedural and critical care sedation in children. The …
and maintenance of anesthesia and procedural and critical care sedation in children. The …
Dexmedetomidine protects the developing rat brain against the neurotoxicity wrought by sevoflurane: role of autophagy and Drp1–Bax signaling
Y Shan, S Sun, F Yang, N Shang… - Drug design, development …, 2018 - Taylor & Francis
Background The effect of sevoflurane on the nervous system is controversial. As an adjuvant
anesthetic, dexmedetomidine has a protective role in various nerve-injury diseases. We …
anesthetic, dexmedetomidine has a protective role in various nerve-injury diseases. We …
RETRACTED ARTICLE: Impact of postoperative dexmedetomidine infusion on incidence of delirium in elderly patients undergoing major elective noncardiac surgery …
Y Sun, M Jiang, Y Ji, Y Sun, Y Liu… - Drug Design …, 2019 - Taylor & Francis
Sun Y, Jiang M, Ji Y, Sun Y, Liu Y, Shen W. Drug Des Devel Ther. 2019; 13: 2911–2922. At
the author's request, we the Editors and Publisher of Drug Design, Development and …
the author's request, we the Editors and Publisher of Drug Design, Development and …
[HTML][HTML] Current evidence on cell death in preterm brain injury in human and preclinical models
AC Truttmann, V Ginet, J Puyal - Frontiers in cell and developmental …, 2020 - frontiersin.org
Despite tremendous advances in neonatal intensive care over the past 20 years, prematurity
carries a high burden of neurological morbidity lasting lifelong. The term encephalopathy of …
carries a high burden of neurological morbidity lasting lifelong. The term encephalopathy of …
Dexmedetomidine attenuates the neurotoxicity of propofol toward primary hippocampal neurons in vitro via Erk1/2/CREB/BDNF signaling pathways
Y Tu, Y Liang, Y Xiao, J Lv, R Guan, F Xiao… - Drug Design …, 2019 - Taylor & Francis
Background Propofol is a commonly used general anesthetic for the induction and
maintenance of anesthesia and critical care sedation in children, which may add risk to poor …
maintenance of anesthesia and critical care sedation in children, which may add risk to poor …