Employing phenols and phenol derivatives as electrophiles for cross-coupling reactions has
numerous advantages over commonly used aryl halides in terms of environmental …

Conventional methods for carrying out carbon–hydrogen functionalization and carbon–
nitrogen bond formation are typically conducted at elevated temperatures, and rely on …

Conspectus Lewis π acids, particularly high-valent transition metals with vacant orbitals, can
coordinate with unsaturated compounds such as alkynes and alkenes by means of π …

Nucleophilic aromatic substitution (SNAr) is one of the most widely applied reaction classes
in pharmaceutical and chemical research, providing a broadly useful platform for the …

Chemists are generally familiar with polar reactions and radical reactions, in comparison,
are underdeveloped. In the last few years, however, the novel concept of amalgamation of …

18F-fluorination is an important and growing field in organic synthesis that has attracted
many chemists in the recent past. Here we present our own, biased perspective with a focus …

Recent developments in experimental and computational chemistry have identified a rapidly
growing class of nucleophilic aromatic substitutions that proceed by concerted (cSNAr) …

A method for deoxyfluorination of aliphatic primary, secondary, and tertiary alcohols is
reported, employing a nontrigonal phosphorus triamide for base-free alcohol activation in …

A mechanistic investigation into the amination of electron-neutral and electron-rich arenes
using organic photoredox catalysis is presented. Kinetic and computational data support …

Nucleophilic aromatic substitution (SNAr) is a classical reaction with well-known reactivity
toward electron-poor fluoroarenes. However, electron-neutral and electron-rich fluoro …