Unconjugated hyperbilirubinemia is a common condition in the first week of postnatal life.
Although generally harmless, some neonates may develop very high levels of unconjugated …

Gilbert's syndrome (GS) is characterized by a benign, mildly elevated bilirubin concentration
in the blood. Recent reports show clear protection from cardiovascular disease in this …

Unconjugated bilirubin (UCB) is responsible for neonatal jaundice and high level of free
bilirubin (Bf) can lead to kernicterus. Previous studies suggest that oxidative stress is a …

Unconjugated bilirubin is considered a potent antioxidant when present at moderate levels.
However, at high concentrations, it produces severe neurological damage and death …

Hyperbilirubinemia (jaundice) is caused by raised levels of unconjugated bilirubin in the
blood. When severe, susceptible brain regions including the cerebellum and auditory …

All pre-term newborns and a high proportion of term newborns develop neonatal jaundice.
Neonatal jaundice is usually a benign condition and self-resolves within few days after birth …

Objective Jaundice (icterus) is the visible manifestation of the accumulation of bilirubin in the
tissue and is indicative of potential toxicity to the brain. Since its very first description more …

Research on the mechanisms of bilirubin-induced neurological dysfunction focuses mainly
on neuronal death, astrocyte-mediated events and microglia activation. Although myelin …

Unconjugated bilirubin (UCB) in newborns may lead to bilirubin neurotoxicity. Few studies
investigated the activation of endoplasmic reticulum stress (ER stress) by UCB. We …

Background Severe hyperbilirubinemia is toxic during central nervous system development.
Prolonged and uncontrolled high levels of unconjugated bilirubin lead to bilirubin-induced …