Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders with a high
prevalence and impact on society. ASDs are characterized by deficits in both social behavior …

Selection of the translational initiation site in most eukaryotic mRNAs appears to occur via a
scanning mechanism which predicts that proximity to the 5′ end plays a dominant role in …

▪ Abstract The forebrain comprises an intricate set of structures that are required for some of
the most complex and evolved functions of the mammalian brain. As a reflection of its …

The conventional scheme of cortical formation shows that postmitotic neurons migrate away
from the germinal ventricular zone to their positions in the developing cortex, guided by the …

Male embryonic mice with mutations in the X-linked aristaless-related homeobox gene (Arx)
developed with small brains due to suppressed proliferation and regional deficiencies in the …

Human evolution is characterized by a dramatic increase in brain size and complexity. To
probe its genetic basis, we examined the evolution of genes involved in diverse aspects of …

Abstract Heterozygous deletions of 17p13. 3 result in the human neuronal migration
disorders isolated lissencephaly sequence (ILS) and the more severe Miller–Dieker …

Mutations in the human LIS1 gene cause the smooth brain disease classical lissencephaly.
To understand the underlying mechanisms, we conducted in situ live cell imaging analysis …

The 14-3-3 proteins are a family of highly conserved, multifunctional proteins that are highly
expressed in the brain during development. Cumulatively, the seven 14-3-3 isoforms make …

Coordinated migration of newly born neurons to their prospective target laminae is a
prerequisite for neural circuit assembly in the developing brain. The evolutionarily …