Resolving the paradox of colon cancer through the integration of genetics, immunology, and the microbiota

M Fidelle, S Yonekura, M Picard, A Cogdill… - Frontiers in …, 2020 - frontiersin.org
While colorectal cancers (CRC) are paradigmatic tumors invaded by effector memory
lymphocytes, the mechanisms accounting for the relative resistance of MSI negative CRC to …

The controversial role of intestinal mast cells in colon cancer

R Molfetta, R Paolini - Cells, 2023 - mdpi.com
Mast cells are tissue-resident sentinels involved in large number of physiological and
pathological processes, such as infection and allergic response, thanks to the expression of …

NK cells and other cytotoxic innate lymphocytes in colorectal cancer progression and metastasis

C Fionda, G Scarno, H Stabile, R Molfetta… - International journal of …, 2022 - mdpi.com
Colorectal cancer (CRC) is one of the most common malignancies and leading causes of
cancer-related deaths worldwide. Despite its complex pathogenesis and progression, CRC …

Epidemiology and molecular-pathologic characteristics of CpG Island methylator phenotype (CIMP) in colorectal cancer

SM Advani, MD Swartz, J Loree, JS Davis… - Clinical colorectal …, 2021 - Elsevier
Background CpG island methylator phenotype (CIMP) forms a distinct epigenetic phenotype
in colorectal cancer (CRC). Though associated with distinct clinicopathologic characteristics …

Potential of olive oil and its phenolic compounds as therapeutic intervention against colorectal cancer: a comprehensive review

A Sain, S Sahu, D Naskar - British Journal of Nutrition, 2022 - cambridge.org
Colorectal cancer (CRC) is one of the major causes of death across the world and incidence
rate of CRC increasing alarmingly each passing year. Diet, genomic anomalies …

Meta‐Analysis of the Prognostic and Predictive Role of the CpG Island Methylator Phenotype in Colorectal Cancer

J Wang, Z Deng, X Lang, J Jiang, K Xie, S Lu… - Disease …, 2022 - Wiley Online Library
Background. Various studies have produced contradictory results on the prognostic role of
the CpG island methylator phenotype (CIMP) among colorectal cancer (CRC) patients …

Gastrointestinal microbiota dysbiosis associated with SARS-CoV-2 infection in colorectal cancer: the implication of probiotics

F Odun-Ayo, L Reddy - Gastroenterology Insights, 2022 - mdpi.com
The complexity of coronavirus disease 2019 (COVID-19)'s pathophysiology is such that
microbial dysbiosis in the lung and gastrointestinal (GI) microbiota may be involved in its …

[HTML][HTML] Advances in CpG island methylator phenotype colorectal cancer therapies

X Zhang, W Zhang, P Cao - Frontiers in Oncology, 2021 - frontiersin.org
With the aging of the population, the incidence of colorectal cancer in China is increasing.
One of the epigenetic alterations: CpG island methylator phenotype (CIMP) plays an …

A multi-omics overview of colorectal cancer to address mechanisms of disease, metastasis, patient disparities and outcomes

G Yang, X Yu, DJ Weisenberger, T Lu, G Liang - Cancers, 2023 - mdpi.com
Simple Summary Human colorectal cancer (CRC) is a global health burden, most notably for
minority populations. While screening tools have helped improve disease detection and …

Genomic effect of DNA methylation on gene expression in colorectal cancer

J Hong, JK Rhee - Biology, 2022 - mdpi.com
Simple Summary Abnormal DNA methylation is known to regulate gene expression, and its
features have been frequently observed in colorectal cancer (CRC) patients. In addition …