The reversible phosphorylation of proteins is accomplished by opposing activities of kinases
and phosphatases. Relatively few protein serine/threonine phosphatases (PSPs) control the …

AMP-activated protein kinase (AMPK) is a fundamental regulator of energy metabolism,
stress resistance, and cellular proteostasis. AMPK signaling controls an integrated signaling …

Protein phosphatases are the essential opposite to protein kinases; together, these enzymes
regulate all protein phosphorylation and most cellular processes. To better understand the …

Phosphatases are crucially involved in cellular processes by dephosphorylating cellular
components. We describe a structure-based classification scheme for all active human …

Aberrant protein phosphorylation is one of the hallmarks of cancer cells, and in many cases
a prerequisite to sustain tumor development and progression. Like protein kinases, protein …

Although a great deal of progress has been made toward understanding the role of abscisic
acid (ABA) in fruit ripening, many components in the ABA signalling pathway remain to be …

Reversible phosphorylation is a key mechanism that regulates many cellular processes in
prokaryotes and eukaryotes. In prokaryotes, signal transduction includes two-component …

This article describes a hitherto unreported involvement of the phosphatase PP 2 C m, a
recently described member of the branched‐chain α‐keto acid dehydrogenase (BCKDH) …

Toll-like receptors (TLRs) are critical sensors for the detection of potentially harmful
microbes. They are instrumental in initiating innate and adaptive immune responses against …

The cellular response to DNA damage is a crucial surveillance mechanism that maintains
genomic integrity and prevents cancer progression. Previous studies identified multiple …