The coevolution of host-pathogen interactions underlies many human physiological traits
associated with protection from or susceptibility to infections. Among the mechanisms that …

Caspase-2 was discovered almost three decades ago. It was one of the first two mammalian
homologs of CED-3, the other being interleukin 1β-converting enzyme (ICE/caspase-1) …

Unscheduled increases in ploidy underlie defects in tissue function, premature aging, and
malignancy. A concomitant event to polyploidization is the amplification of centrosomes, the …

Centrosome amplification results into genetic instability and predisposes cells to neoplastic
transformation. Supernumerary centrosomes trigger p53 stabilization dependent on the …

Caspase-2 belongs to the caspase family of proteins responsible for essential cellular
functions including apoptosis and inflammation. Uniquely, caspase-2 has been identified as …

The cleavage of nuclear proteins by caspases promotes nuclear breakdown and, therefore,
plays a key role in apoptosis execution. However, the detailed molecular mechanisms of …

Members of the caspase family are well known for their roles in the initiation and execution
of cell death. Due to their function in the removal of damaged cells that could otherwise …

Cellular responses to stimuli can evolve over time, resulting in distinct early and late phases
in response to a single signal. DNA damage induces a complex response that is largely …

We previously demonstrated that CRM1, a major nuclear export factor, accumulates at Hox
cluster regions to recruit nucleoporin-fusion protein Nup98HoxA9, resulting in robust …

Interleukin-1 receptor (IL-1R)–associated kinases (IRAKs) are core effectors of Toll-like
receptors (TLRs) and IL-1R in innate immunity. Here, we found that IRAK4 and IRAK1 …