Stalling of ribosomes engaged in protein synthesis can lead to significant defects in the
function of newly synthesized proteins and thereby impair protein homeostasis …

During translation, messenger RNAs (mRNAs) are decoded by ribosomes which can stall for
various reasons. These include chemical damage, codon composition, starvation, or …

The prokaryotic translation elongation factor P (EF-P) and the eukaryotic/archaeal
counterparts eIF5A/aIF5A are proteins that serve a crucial role in mitigating ribosomal …

Efficiency of protein synthesis on the ribosome is strongly affected by the amino acid
composition of the assembled amino acid chain. Challenging sequences include proline …

In actively translating 80S ribosomes the ribosomal protein eS7 of the 40S subunit is
monoubiquitinated by the E3 ligase Not4 and deubiquitinated by Otu2 upon ribosomal …

The degradation of damaged proteins is critical for tissue integrity and organismal health
because damaged proteins have a high propensity to form aggregates. E3 ubiquitin ligases …

The strategies adopted by viruses to reprogram the translation and protein quality control
machinery and promote infection are poorly understood. Here, we report that the viral …

Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes that ligate amino acids to
tRNAs, and often require editing to ensure accurate protein synthesis. Recessive mutations …

Cellular senescence is characterized by a permanent growth arrest and is associated with
tissue aging and cancer. Senescent cells secrete a number of different cytokines referred to …

Ribosomes trapped on mRNAs during protein synthesis need to be rescued for the cell to
survive. The most ubiquitous bacterial ribosome rescue pathway is trans-translation …