Bone marrow stromal cells are progenitors of skeletal tissue components such as bone,
cartilage, the hematopoiesis-supporting stroma, and adipocytes. In addition, they may be …

Abstract Background Matrix vesicles (MVs) are released from hypertrophic chondrocytes
and from mature osteoblasts, the cells responsible for endochondral and membranous …

Pamela G. Robey, Editor appear and begin to function. The primitive bony collar established
by these osteoblasts becomes eroded by osteoclasts to allow vascular invasion and the …

Growth plate chondrocytes play a pivotal role in promoting longitudinal bone growth. The
current review represents a brief survey of the phenomena involved in this process at the …

According to the general understanding, the chondrocyte lineage terminates with the
elimination of late hypertrophic cells by apoptosis in the growth plate. However, recent cell …

The extracellular matrix (ECM) is a complex of self assembled macromolecules. It is
composed predominantly of collagens, non-collagenous glycoproteins, hyaluronan and …

Stromal cells generated in long-term cultures appear to follow a vascular smooth muscle
differentiation pathway. Such a pathway, comprising several steps hallmarked by the …

During endochondral bone development, bone‐forming osteoblasts have to colonize the
regions of cartilage that will be replaced by bone. In adulthood, bone remodeling and repair …

Data obtained while investigating growth plate chondrocyte differentiation during
endochondral bone formation both in vivo and in vitro indicate that initial chondrogenesis …

We have investigated the early cellular events that take place during the change in lineage
commitment from hypertrophic chondrocytes to osteoblast-like cells. We have induced this …