Centrioles are conserved microtubule-based organelles that form the core of the centrosome
and act as templates for the formation of cilia and flagella. Centrioles have important roles in …

Whole-genome and centrosome duplication as a consequence of cytokinesis failure can
drive tumorigenesis in experimental model systems. However, whether cytokinesis failure is …

Centrosome amplification is a common feature of human tumors, but whether this is a cause
or a consequence of cancer remains unclear. Here, we test the consequence of centrosome …

Mitosis is a delicate event that must be executed with high fidelity to ensure genomic
stability. Recent work has provided insight into how mitotic errors shape cancer genomes by …

Operating at multiple levels of control, mesenchymal stem cells from adipose tissue (ADSCs)
communicate with organ systems to adjust immune response, provide signals for …

Centrosomes, the main microtubule-organizing centers in animal cells, are replicated
exactly once during the cell division cycle to form the poles of the mitotic spindle …

The polo family serine threonine kinase Plk4 has been proposed as a therapeutic target in
advanced cancers based on increased expression in primary human cancers, facilitation of …

The centriole is a multifunctional structure that organizes centrosomes and cilia and is
important for cell signaling, cell cycle progression, polarity, and motility. Defects in centriole …

The development of complex stratified epithelial barriers in mammals is initiated from single-
layered epithelia. How stratification is initiated and fueled are still open questions. Previous …

Centrosomes are microtubule-organizing centers that facilitate bipolar mitotic spindle
assembly and chromosome segregation. Recognizing that centrosome amplification is a …