Simple Summary As cell cycle checkpoint mechanisms maintain genomic integrity, the
inhibition of enzymes involved in these control mechanisms may increase the sensitivity of …

We investigated the anti-tumour effects and the underlying molecular mechanisms of a new
oral histone deacetylase inhibitor (HDACi), chidamide, in NK/T cell lymphoma (NKTCL), a …

Objectives In head and neck squamous cell carcinoma (HNSCC), poor prognosis and low
survival rates are associated with downregulated calprotectin. Calprotectin (S100A8/A9) …

Background/Aim: Retinoblastoma (RB) is the most common primary intraocular malignancy.
Carboplatin (CPt) is a DNA damage-inducing agent that is widely used for the treatment of …

Prostate cancer (PCa) is a common and deadly disease in men. It is often diagnosed at
advanced stages, at which point patients are treated mainly with docetaxel (DTX), which is …

Cancers are a high risk for humanity. In 2018, approximately 18 million new cancer cases
were diagnosed in the world. The choice of treatment depends on the type of cancer and its …

Pierwsze badania kliniczne z zastosowaniem heksametylomelaminy przeprowadzono w
1965 r., a dalsze badania aktywności wykazały, że w połączeniu z innymi lekami …

I centrosomi sono organelli cellulari a base di microtubuli, composti da due centrioli e dal
materiale pericentriolare che li circonda. I centrosomi sono coinvolti nell'organizzazione dei …

BACKGROUND: Cellular senescence is known to be correlated with the cessation of cell
cycle. The progression of cell cycle is promoted by activities of various proteins, including …

BACKGROUND: In the senescence process, the retinoblastoma (Rb) protein binds to E2F in
hypophosphorylated conditions, preventing the cell to enter the S-phase in the cell cycle …