Recent advances in the development of new strategies in nucleophilic, electrophilic, and
radical trifluoromethylations are reviewed. The emphasis is given to the description of the …

The introduction of a fluorine atom or perfluoroalkyl group, particularly a trifluoromethyl
group, into an organic compound can bring about remarkable changes in the physical …

Trimethylsilyl nucleophiles (Me3SiNu), with silicon atoms attached to carbon, nitrogen,
oxygen, or sulfur atoms, have long been recognized as effective alternatives for proton …

The paper reviews our recent findings on the trifluoromethylation of organic compounds
using TMSCF3. Direct preparation of trifluoromethylated ketones from esters, amides from …

CH activation involves any of a wide range of techniques, often using catalysts in which a
carbon to hydrogen covalent bond of an organic compound is cleaved to replace the …

Trifluoromethylated amines are important building blocks for pharmaceutical research.[1]
The CF3 group, because of its strongly electron withdrawing nature, lowers the basicity of …

HBTM-2.1 promotes the catalytic asymmetric intermolecular Michael-lactonisation of
arylacetic acids and trifluoromethylenones in the presence of pivaloyl chloride, giving C (6) …

All domains of society are impacted by fluorine chemistry. In particular, fluorine plays a key
role in medicinal, pharmaceutical and agrochemical sciences in which the synthesis and …

The benzoyl peroxide (BPO)-promoted oxidative functionalization of tertiary amines under
transition-metal-free reaction conditions was developed. Various 1-trifluoromethylated …

In recent years increasing interest has been devoted to widen the scope of the formerly
studied reaction of nitrones with Grignard reagents to different nucleophilic compounds …