Coronavirus membrane fusion mechanism offers a potential target for antiviral development
Abstract The coronavirus disease 2019 (COVID-19) pandemic has focused attention on the
need to develop effective therapies against the causative agent, SARS-CoV-2, and also …
need to develop effective therapies against the causative agent, SARS-CoV-2, and also …
The SARS-coronavirus infection cycle: a survey of viral membrane proteins, their functional interactions and pathogenesis
NA Wong, MH Saier Jr - International journal of molecular sciences, 2021 - mdpi.com
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a novel epidemic
strain of Betacoronavirus that is responsible for the current viral pandemic, coronavirus …
strain of Betacoronavirus that is responsible for the current viral pandemic, coronavirus …
Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is initiated by
virus binding to the ACE2 cell-surface receptors,,–, followed by fusion of the virus and cell …
virus binding to the ACE2 cell-surface receptors,,–, followed by fusion of the virus and cell …
TMPRSS2 expression dictates the entry route used by SARS‐CoV‐2 to infect host cells
J Koch, ZM Uckeley, P Doldan, M Stanifer… - The EMBO …, 2021 - embopress.org
SARS‐CoV‐2 is a newly emerged coronavirus that caused the global COVID‐19 outbreak in
early 2020. COVID‐19 is primarily associated with lung injury, but many other clinical …
early 2020. COVID‐19 is primarily associated with lung injury, but many other clinical …
Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination
INTRODUCTION The clinical manifestations of COVID-19 vary from asymptomatic infection
to respiratory failure. Severe disease courses are primarily associated with advanced age …
to respiratory failure. Severe disease courses are primarily associated with advanced age …
Phylogenetic analysis and structural modeling of SARS-CoV-2 spike protein reveals an evolutionary distinct and proteolytically sensitive activation loop
Abstract The 2019 novel coronavirus (2019-nCoV/SARS-CoV-2) originally arose as part of a
major outbreak of respiratory disease centered on Hubei province, China. It is now a global …
major outbreak of respiratory disease centered on Hubei province, China. It is now a global …
Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis
Severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2002 as a highly
transmissible pathogenic human betacoronavirus. The viral spike glycoprotein (S) utilizes …
transmissible pathogenic human betacoronavirus. The viral spike glycoprotein (S) utilizes …
SARS-CoV-2 spike engagement of ACE2 primes S2′ site cleavage and fusion initiation
S Yu, X Zheng, B Zhou, J Li, M Chen… - Proceedings of the …, 2022 - National Acad Sciences
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection has resulted in tremendous loss worldwide. Although viral spike (S) …
(SARS-CoV-2) infection has resulted in tremendous loss worldwide. Although viral spike (S) …
Genomic determinants of pathogenicity in SARS-CoV-2 and other human coronaviruses
AB Gussow, N Auslander, G Faure… - Proceedings of the …, 2020 - National Acad Sciences
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses an immediate, major
threat to public health across the globe. Here we report an in-depth molecular analysis to …
threat to public health across the globe. Here we report an in-depth molecular analysis to …
Cryo-EM structure of SARS-CoV-2 postfusion spike in membrane
The entry of SARS-CoV-2 into host cells depends on the refolding of the virus-encoded
spike protein from a prefusion conformation, which is metastable after cleavage, to a lower …
spike protein from a prefusion conformation, which is metastable after cleavage, to a lower …