Transient or permanent loss of tissue perfusion due to ischaemic stroke can lead to damage
to the neurovasculature, and disrupt brain homeostasis, causing long-term motor and …

As extremely sensitive immune cells, microglia act as versatile watchdogs of the central
nervous system (CNS) that tightly control tissue homeostasis. Therefore, microglial activation …

The major neuropathological hallmarks of Alzheimer's disease (AD) are amyloid β (Aβ)
plaques and neurofibrillary tangles (NFT), accompanied by neuroinflammation and neuronal …

Chronic neuroinflammation with sustained microglial activation occurs following severe
traumatic brain injury (TBI) and is believed to contribute to subsequent neurodegeneration …

Unraveling the fine structure of the brain is important to provide a better understanding of its
normal and abnormal functioning. Application of high-resolution electron microscopic …

Spinal cord injury (SCI) remains a challenging clinical problem worldwide, due to the lack of
effective drugs for precise treatment. Among the complex pathophysiological events …

Glia, a non-excitable cell type once considered merely as the connective tissue between
neurons, is nowadays acknowledged for its essential contribution to multiple physiological …

The spread of neurodegeneration through the human brain network is reported as
underlying the progression of neurodegenerative disorders. However, the exact …

Background Astrocyte over-activation and extensive neuron loss are the main characteristic
pathological features of spinal cord ischemia–reperfusion injury (SCII). Prior studies have …

Alcoholism is one of the most common diseases that can lead to the development of several
chronic diseases including steatosis, and cognitive dysfunction. Statins are lipid-lowering …