Cardiorenal syndromes have been categorized into 5 clinical subtypes based on which
organ is perceived to be the primary precipitant of the vicious and interrelated cycle of …

The prevalence of heart failure is increasing in the western world. Current efforts aim to
identify heart failure at its earliest and preclinical stages in order to begin treatment and …

Background: Multiple epidemiological studies from Europe and Asia have demonstrated
increased cardiovascular risks associated with isolated elevation of home blood pressure …

Background—Cystatin C (CyC) is more sensitive than serum creatinine (sCr) to rapidly
detect acute changes in renal function. Methods and Results—We measured CyC together …

Background: Few data are available comparing cardiovascular disease (CVD) biomarker
profiles between women and men in the general population. We analyzed sex-based …

Galectin-3 plays an important role in fibroblast activation and fibrosis in animal models.
Increased galectin-3 levels are associated with poor long-term survival in heart failure (HF) …

Cystatin C (cys-C) is a small protein molecule (120 amino acid peptide chain, approximately
13kDa) produced by virtually all nucleated cells in the human body. It belongs to the family …

Abstract The 2014 Canadian Cardiovascular Society Heart Failure Management Guidelines
Update provides discussion on the management recommendations on 3 focused areas:(1) …

The extracellular matrix (ECM) of the heart is composed largely of elastin and collagen and
plays many roles in cardiac wall and valve homeostasis. Maintenance of a healthy cardiac …

Cardiovascular disease is the leading cause of death in the US and other developed
countries. Metabolic syndrome, including obesity, diabetes/insulin resistance, hypertension …