Plant-based phytochemicals as possible alternative to antibiotics in combating bacterial drug resistance

HMA AlSheikh, I Sultan, V Kumar, IA Rather… - Antibiotics, 2020 - mdpi.com
The unprecedented use of antibiotics that led to development of resistance affect human
health worldwide. Prescription of antibiotics imprudently and irrationally in different diseases …

Natural products as a source for novel antibiotics

MG Moloney - Trends in pharmacological sciences, 2016 - cell.com
Natural products have historically been of crucial importance in the identification and
development of antibacterial agents. Interest in these systems has waned in recent years …

Inhibiting bacterial drug efflux pumps via phyto-therapeutics to combat threatening antimicrobial resistance

V Shriram, T Khare, R Bhagwat, R Shukla… - Frontiers in …, 2018 - frontiersin.org
Antibiotics, once considered the lifeline for treating bacterial infections, are under threat due
to the emergence of threatening antimicrobial resistance (AMR). These drug-resistant …

Drug efflux pump inhibitors: a promising approach to counter multidrug resistance in Gram-negative pathogens by targeting AcrB protein from AcrAB-TolC multidrug …

R Alenazy - Biology, 2022 - mdpi.com
Simple Summary Multidrug-resistant bacterial infections, especially that caused by Gram-
negative bacteria, have posed serious health issues worldwide. Bacteria have different …

RND-type drug efflux pumps from Gram-negative bacteria: molecular mechanism and inhibition

H Venter, R Mowla, T Ohene-Agyei, S Ma - Frontiers in microbiology, 2015 - frontiersin.org
Drug efflux protein complexes confer multidrug resistance on bacteria by transporting a wide
spectrum of structurally diverse antibiotics. Moreover, organisms can only acquire resistance …

Antibiotic potentiators against multidrug-resistant bacteria: discovery, development, and clinical relevance

M Chawla, J Verma, R Gupta, B Das - Frontiers in Microbiology, 2022 - frontiersin.org
Antimicrobial resistance in clinically important microbes has emerged as an unmet
challenge in global health. Extensively drug-resistant bacterial pathogens have cropped up …

[HTML][HTML] Plant-derived secondary metabolites as the main source of efflux pump inhibitors and methods for identification

AJ Seukep, V Kuete, L Nahar, SD Sarker… - Journal of pharmaceutical …, 2020 - Elsevier
The upsurge of multiple drug resistance (MDR) bacteria substantially diminishes the
effectiveness of antibiotic arsenal and therefore intensifies the rate of therapeutic failure. The …

Pharmaceutical approaches to target antibiotic resistance mechanisms

D Schillaci, V Spanò, B Parrino… - Journal of medicinal …, 2017 - ACS Publications
There is urgent need for new therapeutic strategies to fight the global threat of antibiotic
resistance. The focus of this Perspective is on chemical agents that target the most common …

Plant synthetic biology for producing potent phyto-antimicrobials to combat antimicrobial resistance

P Tiwari, T Khare, V Shriram, H Bae, V Kumar - Biotechnology Advances, 2021 - Elsevier
Inappropriate and injudicious use of antimicrobial drugs in human health, hygiene,
agriculture, animal husbandry and food industries has contributed significantly to rapid …

Role of medicinal plants from North Western Himalayas as an efflux pump inhibitor against MDR AcrAB-TolC Salmonella enterica serovar typhimurium: In vitro and In …

J Mehta, R Rolta, K Dev - Journal of Ethnopharmacology, 2022 - Elsevier
Abstract Ethnopharmacological relevance Zingiber officinale Roscoe has been utilized
traditionally to cure various diseases like cold, cough, diarrhoea, nausea, asthma, vomiting …