Meiotic drive mechanisms: lessons from Drosophila

C Courret, CH Chang, KHC Wei… - … of the Royal …, 2019 - royalsocietypublishing.org
Meiotic drivers are selfish genetic elements that bias their transmission into gametes, often
to the detriment of the rest of the genome. The resulting intragenomic conflicts triggered by …

Resistance to natural and synthetic gene drive systems

TAR Price, N Windbichler, RL Unckless… - Journal of …, 2020 - academic.oup.com
Scientists are rapidly developing synthetic gene drive elements intended for release into
natural populations. These are intended to control or eradicate disease vectors and pests, or …

Rapid evolutionary dynamics of an expanding family of meiotic drive factors and their hpRNA suppressors

J Vedanayagam, CJ Lin, EC Lai - Nature ecology & evolution, 2021 - nature.com
Meiotic drivers are a class of selfish genetic elements whose existence is frequently hidden
due to concomitant suppressor systems. Accordingly, we know little of their evolutionary …

Satellite DNA-mediated diversification of a sex-ratio meiotic drive gene family in Drosophila

CA Muirhead, DC Presgraves - Nature Ecology & Evolution, 2021 - nature.com
Sex chromosomes are susceptible to the evolution of selfish meiotic drive elements that bias
transmission and distort progeny sex ratios. Conflict between such sex-ratio drivers and the …

piRNA-mediated gene regulation and adaptation to sex-specific transposon expression in D. melanogaster male germline

P Chen, AA Kotov, BK Godneeva… - Genes & …, 2021 - genesdev.cshlp.org
Small noncoding piRNAs act as sequence-specific guides to repress complementary targets
in Metazoa. Prior studies in Drosophila ovaries have demonstrated the function of the piRNA …

Impacts of sex ratio meiotic drive on genome structure and function in a stalk-eyed fly

JA Reinhardt, RH Baker, AV Zimin… - Genome Biology and …, 2023 - academic.oup.com
Stalk-eyed flies in the genus Teleopsis carry selfish genetic elements that induce sex ratio
(SR) meiotic drive and impact the fitness of male and female carriers. Here, we assemble …

Essential and recurrent roles for hairpin RNAs in silencing de novo sex chromosome conflict in Drosophila simulans

J Vedanayagam, M Herbette, H Mudgett, CJ Lin… - PLoS …, 2023 - journals.plos.org
Meiotic drive loci distort the normally equal segregation of alleles, which benefits their own
transmission even in the face of severe fitness costs to their host organism. However …

Hybrid Sterility, Genetic Conflict and Complex Speciation: Lessons From the Drosophila simulans Clade Species

DC Presgraves, CD Meiklejohn - Frontiers in genetics, 2021 - frontiersin.org
The three fruitfly species of the Drosophila simulans clade—D. simulans, D. mauritiana, and
D. sechellia—have served as important models in speciation genetics for over 40 years …

Fertility costs of meiotic drivers

SE Zanders, RL Unckless - Current Biology, 2019 - cell.com
In sexual reproduction, opportunities are limited and the stakes are high. This inevitably
leads to conflict. One pervasive conflict occurs within genomes between alternative alleles at …

The wtf meiotic driver gene family has unexpectedly persisted for over 100 million years

M De Carvalho, GS Jia, AN Srinivasa, RB Billmyre… - Elife, 2022 - elifesciences.org
Meiotic drivers are selfish elements that bias their own transmission into more than half of
the viable progeny produced by a driver+/driver− heterozygote. Meiotic drivers are thought …