Meiotic drive mechanisms: lessons from Drosophila
Meiotic drivers are selfish genetic elements that bias their transmission into gametes, often
to the detriment of the rest of the genome. The resulting intragenomic conflicts triggered by …
to the detriment of the rest of the genome. The resulting intragenomic conflicts triggered by …
Resistance to natural and synthetic gene drive systems
Scientists are rapidly developing synthetic gene drive elements intended for release into
natural populations. These are intended to control or eradicate disease vectors and pests, or …
natural populations. These are intended to control or eradicate disease vectors and pests, or …
Rapid evolutionary dynamics of an expanding family of meiotic drive factors and their hpRNA suppressors
J Vedanayagam, CJ Lin, EC Lai - Nature ecology & evolution, 2021 - nature.com
Meiotic drivers are a class of selfish genetic elements whose existence is frequently hidden
due to concomitant suppressor systems. Accordingly, we know little of their evolutionary …
due to concomitant suppressor systems. Accordingly, we know little of their evolutionary …
Satellite DNA-mediated diversification of a sex-ratio meiotic drive gene family in Drosophila
CA Muirhead, DC Presgraves - Nature Ecology & Evolution, 2021 - nature.com
Sex chromosomes are susceptible to the evolution of selfish meiotic drive elements that bias
transmission and distort progeny sex ratios. Conflict between such sex-ratio drivers and the …
transmission and distort progeny sex ratios. Conflict between such sex-ratio drivers and the …
piRNA-mediated gene regulation and adaptation to sex-specific transposon expression in D. melanogaster male germline
P Chen, AA Kotov, BK Godneeva… - Genes & …, 2021 - genesdev.cshlp.org
Small noncoding piRNAs act as sequence-specific guides to repress complementary targets
in Metazoa. Prior studies in Drosophila ovaries have demonstrated the function of the piRNA …
in Metazoa. Prior studies in Drosophila ovaries have demonstrated the function of the piRNA …
Impacts of sex ratio meiotic drive on genome structure and function in a stalk-eyed fly
Stalk-eyed flies in the genus Teleopsis carry selfish genetic elements that induce sex ratio
(SR) meiotic drive and impact the fitness of male and female carriers. Here, we assemble …
(SR) meiotic drive and impact the fitness of male and female carriers. Here, we assemble …
Essential and recurrent roles for hairpin RNAs in silencing de novo sex chromosome conflict in Drosophila simulans
J Vedanayagam, M Herbette, H Mudgett, CJ Lin… - PLoS …, 2023 - journals.plos.org
Meiotic drive loci distort the normally equal segregation of alleles, which benefits their own
transmission even in the face of severe fitness costs to their host organism. However …
transmission even in the face of severe fitness costs to their host organism. However …
Hybrid Sterility, Genetic Conflict and Complex Speciation: Lessons From the Drosophila simulans Clade Species
DC Presgraves, CD Meiklejohn - Frontiers in genetics, 2021 - frontiersin.org
The three fruitfly species of the Drosophila simulans clade—D. simulans, D. mauritiana, and
D. sechellia—have served as important models in speciation genetics for over 40 years …
D. sechellia—have served as important models in speciation genetics for over 40 years …
Fertility costs of meiotic drivers
SE Zanders, RL Unckless - Current Biology, 2019 - cell.com
In sexual reproduction, opportunities are limited and the stakes are high. This inevitably
leads to conflict. One pervasive conflict occurs within genomes between alternative alleles at …
leads to conflict. One pervasive conflict occurs within genomes between alternative alleles at …
The wtf meiotic driver gene family has unexpectedly persisted for over 100 million years
Meiotic drivers are selfish elements that bias their own transmission into more than half of
the viable progeny produced by a driver+/driver− heterozygote. Meiotic drivers are thought …
the viable progeny produced by a driver+/driver− heterozygote. Meiotic drivers are thought …