Degradation of proteins in the extracellular matrix is crucial for the multistep process of
cancer invasion and metastasis. Compelling evidence has demonstrated the urokinase …

The prognostic and/or predictive value of the cancer biomarkers, urokinase-type
plasminogen activator (uPA) and its inhibitor (plasminogen activator inhibitor [PAI]-1) …

From a large combinatorial library of chemically constrained bicyclic peptides we isolated a
selective and potent (K i= 53 nM) inhibitor of human urokinase-type plasminogen activator …

Inorganic nanocrystals such as quantum dots (QDs) and upconverting nanoparticles
(UCNPs) are uniquely suited for quantitative live-cell imaging and are typically …

In cancer, the serine protease urokinase-type plasminogen activator, its inhibitor
(plasminogen activator inhibitor type-1) and the receptor (CD87), among other proteolytic …

Antibodies display great versatility in protein interactions and have become important
therapeutic agents for a variety of human diseases. Their ability to discriminate between …

The increased proteolytic activity of membrane-bound and secreted proteases on the
surface of cancer cells and in the transformed stroma is a common characteristic of …

Human monoclonal antibodies (mAbs) can routinely be isolated from phage display libraries
against virtually any protein available in sufficient purity and quantity, but library design can …

Urokinase-type plasminogen activator (uPA) is a trypsin-like serine protease that plays a
vital role in extracellular conversion of inactive plasminogen into catalytically active plasmin …

目的探讨尿激酶纤维蛋白溶酶原激活物(urokinase plasminogen activator, uPA)
系统在肺癌患者中的变化, 分析并评价其与肺癌患者预后的关系. 方法记录肺癌患者化疗前 …