Studies of epilepsy in mutant mice provide a framework for understanding critical features of
the brain that regulate excitability. These, and as yet undiscovered, mouse mutants will …

Background Epilepsy is a common neurological disorder, which is attributed to
uncontrollable abnormal hyper-excitability of neurons. We investigated the feasibility of …

The intravenous pentylenetetrazol (iv PTZ) seizure test provides threshold dose for induction
of seizures in individual animals. In the present study, the iv and sc PTZ seizure models in …

Many patients with epilepsy do not obtain proper control of their seizures through
conventional treatment. We review aspects of the pathophysiology underlying epileptic …

Larval zebrafish (Danio rerio) have recently been suggested as a high-throughput
experimental model of epilepsy-related pathogenetic states. Here we use adult zebrafish to …

In preclinical studies, implanted electrodes can cause severe degradation of MRI images
and hence are seldom used for chronic studies employing functional magnetic resonance …

Purpose: The astrocyte‐specific glutamine synthetase (GS) plays a key role in glutamate
recycling and Gamma‐aminobutyric acid (GABA) metabolism. Changes in the expression or …

Diagnosis of ongoing epileptogenesis and associated hyperexcitability after brain injury is a
major challenge. Given that increased neuronal activity in the brain triggers a blood …

We report on a miniature label-free imaging system for monitoring brain blood flow and
blood oxygenation changes in awake, freely behaving rats. The device, weighing 15 grams …

Simultaneous electrophysiological and functional magnetic resonance imaging
measurements of animal models of epilepsy are methodologically challenging, but essential …